College Football Week 4 Best Bets: Odds & Predictions for September 26

If you have been pining for more competitive games in college football, then you’ll love this weekend’s slate. Why? Because we have six games featuring ranked vs. ranked matchups Saturday, giving us plenty of choices for this week’s CFB Best Bets list.

Let’s take a look at the betting line for a few of these games and discuss how to bet on them.

(Photo by Kenneth Richmond/Getty Images)

College Football Odds for Week 4 (Saturday)

The 2026-27 college football season is taking shape, and this list of the best sports betting offers will help you when making CFB and sports bets.

Here are the betting lines for a few of Saturday’s ranked vs. ranked matchups with odds via FanDuel:

No. 1 Texas Longhorns vs. No. 14 Tennessee Volunteers

• Spread: Texas -4.5 (-114) | Tennessee +4.5 (-105)
• Moneyline: Texas -210 | Tennessee +172
• Total: O/U 54.5 (-112/-108)

At these odds, Texas has a 67.74% chance of beating Tennessee art Neyland Stadium Saturday. The odds give Tennessee a 36.76% chance of upsetting the No. 1 Longhorns. However, while the outcome of the game is important, of course, one of the more interesting storylines is the potential impact of a sitting president attending the game.

Aside from the Army-Navy games, Donald Trump attended several games during his time as president: the 2018, 2020, and 2026 national championship games, as well as LSU-Alabama in 2020. In those games, the betting favorite went 3-1 SU but only 1-3 ATS.

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No. 4 Ole Miss Rebels vs. No. 21 Florida Gators

• Spread: Ole Miss +3.5 (-120) | Florida -3.5 (-102)
• Moneyline: Ole Miss +130 | Florida -156
• Total: O/U 58.5 (-115/-105)

This is an interesting line because the Rebels are the No. 4 team in the nation, with wins over two ranked teams under their belt this early in the season. But despite the early success Ole Miss has enjoyed, it is an underdog heading into this matchup.

The line opened with the Gators favored by 1.5 to 3 points depending on the sportsbook but appears to have settled at Florida -3.5 as kickoff nears.

It seems like a crazy notion to me, but it is not an altogether uncommon occurrence. Just this season, we saw No. 1 Ohio State as a 2.5-point underdog to then-No. 4 Texas in Austin. Just last week, No. 23 Louisville was a 1.5-point favorite at home against No. 16 SMU. Both favorites won outright, but Texas failed to cover.

No. 17 Iowa Hawkeyes vs. No. 18 Michigan Wolverines

• Spread: Iowa +5.5 (-112) | Michigan -5.5 (-108)
• Moneyline: Iowa +180 | Michigan -220
• Total: O/U 38.5 (-110/-110)

Like Ole Miss vs. Florida, this is another game where the better-ranked team is the underdog. However, history certainly favors the Wolverines. Iowa hasn’t beaten Michigan since the 2016 season, a string of five consecutive wins for the Wolverines.

Iowa hasn't beaten Michigan in Ann Arbor since 2010.

CFB Best Bets: No. 1 Texas Longhorns vs. No. 14 Tennessee Volunteers

Texas was expected to be a national title contender entering the season, so seeing them ranked No.1 in the country shouldn’t come as a surprise. Yes, the Longhorns earned the spot after an incredible come-from-behind win over then-No. 1 Ohio State.

But are they as good as the No. 1 team in the country should be? A case could be made for “yes” simply because they found a way to win against the Buckeyes despite not playing well for three quarters of the game. That is the kind of thing a championship-caliber team can do. But beyond that moment, they have not played the part.

Take away the fourth-quarter comeback and the offense has been pedestrian. Yes, Texas beat up Texas State in Week 1, as it should. But Arch Manning completed just 50% of his passes against UTSA last week for 161 yards and two scores. To be fair, he didn’t need to do much against the Roadrunners with the run game going for 231 yards. But a Heisman Trophy candidate and potential No. 1 pick should complete more than 50% of his passes no matter who he plays.

While the run game saved the day against UTSA, it ranks ninth in the conference with 176 yards per game.

Now, Tennessee does not have a great run defense (No. 14 in the SEC, 138 yards per game allowed). That could play into the strength of the Texas offense. But a better question may be whether Texas can stop a Tennessee run game ranked No. 1 in the conference and No. 4 in the nation (averaging 298.7 yards per game).

My Pick: Tennessee ML (+172, FanDuel)

From a national perspective, Texas has been decent against the run this season (No. 48). But according to SEC standards, it ranks No. 10 in the conference (109 yards per game allowed). Texas may not be able to lean on its own run game to keep the Vols off the field with Hollywood Smothers questionable for the game.

Texas will have to lean on Arch Manning, which may not be easy to do against a fierce Tennessee pass rush (third in the nation in sacks). Manning completed under 50% of his passes when under pressure in 2025 and earned a dismal 35.3 when under pressure against Ohio State (according to PFF).

What helped Manning lead the comeback against Ohio State was a relatively clean pocket that gave him more than three seconds to throw. That is a luxury he is not likely to have against this Tennessee defense. The Vols have the No. 19 pass defense in the country and the No. 2 unit in the SEC.

This will be a low-scoring game (making the under a viable play), with defense controlling the first half. But the Tennessee run game will break through in the second half and lead the Vols to a win.

CFB Best Bets: No. 4 Ole Miss Rebels vs. No. 21 Florida Gators

Oddsmakers got this line wrong. There is no way the Rebels, the No. 4 team in the country, should be an underdog to Florida. Yes, I say that even though the game is at The Swamp in Gainesville.

The trick at this stage of the season is gauging just how good a team really is. Ole Miss has defeated two ranked teams. Heisman candidate Trinidad Chambliss leads an offense ranked No. 8 in the country (and first in the SEC) in passing, No. 1 in the red zone, and No. 3 in sacks allowed. The run game hasn’t been great, but Kewan Lacy has been dealing with injuries.

The Rebels aren't a particularly strong defensive team, but with an offense that scores 36.9 points per game (No. 10 in the country, No. 3 in the SEC), they can get away with it.

On paper, Florida looks incredible. The Gators have the No. 2 scoring offense in the nation and the SEC (54 points per game allowed). The Gators run the ball well (246 yards per game; No. 4 in the conference) and have held teams to under 100 yards per game on the ground. Florida also owns the No. 3 passing game in the SEC (298.3 yards per game).

The Florida defense ranks better than Ole Miss’s in several ways, but it is worth noting who the Gators have played: Florida Atlantic (2-1 so far this season, 4-8 in 2025), Campbell (an FCS team), and Auburn (2-1 this season, 5-7 in 2025).

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My Pick: Ole Miss ML (+130, FanDuel)

Florida is overrated, plain and simple. It has yet to face a competitive team; Auburn is not bad, but the Tigers were also a sub-.500 team last year. They aren’t that good either. An SEC team beating up on a Group of Six and an FCS team just isn’t impressive. Ole Miss has played quality competition from the ACC and SEC and won. The Rebels are a proven commodity, unlike the Gators.

The most common argument in favor of the Gators that I’ve seen is that Ole Miss hasn’t won at The Swamp since 2008. Yes, that is a long time, but not when you consider that Ole Miss and Florida have only played five times since 2008, with three of those games in Gainesville.

The Gators have inflated stats thanks to playing lackluster competition. Ole Miss has solid stats earned against good teams. The Rebels will expose Florida and easily win this one. Take the Ole Miss moneyline.

CFB Best Bets: No. 17 Iowa Hawkeyes vs. No. 18 Michigan Wolverines

Michigan needs to win this game. After coming into the season with high hopes, the Wolverines have largely been a disappointment. Western Michigan beat them everywhere but the scoreboard in the season opener. They showed improvement in Week 2 against a then-No. 11 Oklahoma team, 17-10.

Last week, they beat up on UTEP, 52-17. This game could show that the early struggles were nothing more than that and that this team is ready to be a force in the Big Ten and national championship picture this season.

So, is all right in the world in Ann Arbor? No! The offense has been terrible. It is the worst in the Big Ten in passing, 16th in scoring, and 13th in running the ball. Defensively, the Wolverines' numbers are a lot better, but will that be enough against their first-ranked opponent of the year?

Like Michigan, Iowa is not great in the passing game (No. 15 in the Big Ten). But its run game looks formidable on paper, No. 10 in the country and No. 2 in the conference (268 yards per game). Its defense, however, looks incredible (on paper):

• No. 1 in the country and Big Ten in scoring (4.3 points per game allowed.
• No. 11 in the country and first in the Big Ten against the run (66 yards per game allowed).
• No. 5 in the country and No. 2 in the conference against the pass (110.7 yards per game allowed).

However, those stats were generated against Northern Illinois (0-3), Iowa State (2-1), and Northern Iowa (a 1-2 FCS team).

My Pick: UNDER 38.5 (-110, FanDuel)

Part of me really wants to take the Hawkeyes to win because Michigan is being overrated here. Yes, the Michigan defense is solid, but the offense is garbage. Iowa looks fantastic on paper because it hasn't played anyone yet, but the Hawkeyes typically have a strong defense. Just because it hasn't been tested doesn’t mean it isn’t solid.

So, I expect the Iowa defense to make Michigan’s offense look much like Western Michigan did in the opener. Thus, making it a solid bet to win this game. However, while Iowa will likely limit the Michigan offense, the same is true the other way around. Michigan’s defense will bring Iowa’s offense back down to earth in a low-scoring game, making the UNDER the best bet for this game.