NBA Picks Today: Denver Nuggets vs Philadelphia 76ers Betting Odds and Predictions on January 21

Winners of six of their last seven, the Denver Nuggets gun for its third straight win while the Philadelphia 76ers hope to snap a six-game losing skid as they collide this Tuesday at Ball Arena.

Boston Celtics v Philadelphia 76ers - Game Six

(Photo by Tim Nwachukwu/Getty Images)

“Denver recorded its second consecutive win following a 113-100 destruction of the Orlando Magic while Philadelphia dropped its sixth straight defeat after losing to the Milwaukee Bucks on Sunday.”

  • Early Denver Nuggets vs Philadelphia 76ers betting lines have three-time league Most Valuable Player (MVP) Nikola Jokic and the Nuggets as the heavy 12-point favorites in this highly-anticipated matchup versus the 76ers.
  • It is, however, worth noting that the 76ers have been no pushover away from home this season, having covered the spread 10 times in 22 road games.
  • This will be the first matchup between the 76ers and the Nuggets this season with each team picking up a win in their two-game series last year.

Will the Nuggets sustain its winning momentum and pull off another blowout win or will the 76ers get out of their current slump in style?

Keep scrolling as we find out how both teams fare with one another in this in-depth Denver Nuggets vs Philadelphia 76ers sports betting predictions article.

Denver Nuggets vs Philadelphia 76ers DraftKings NBA Odds for January 21

Moneyline

  • Denver Nuggets: -700
  • Philadelphia 76ers: +500

Spread

  • Denver Nuggets: -12 (-110)
  • Philadelphia 76ers: +12 (-110)

Over/Under (Total)

  • OVER 227.5 (-110)
  • UNDER 227.5 (-110)

Denver Nuggets vs Philadelphia 76ers Injury Report

Denver Nuggets Injury Report

  1. Vlatko Cancar – Knee – Out
  2. DaRon Holmes II – Out

Philadelphia 76ers Injury Report

  1. Jared McCain – Knee – Out
  2. Joel Embiid – Knee – Out
  3. KJ Martin – Foot – Out
  4. Andre Drummond – Toe – Day-to-Day
  5. Caleb Martin – Hip – Day-to-Day
  6. Kyle Lowry – Hip – Day-to-Day
  7. Paul George – Groin – Questionable
  8. Guerschon Yabusele – Knee – Questionable

Best NBA odds for Denver Nuggets vs Philadelphia 76ers

  • The Denver Nuggets have been beating teams by nearly 17 points in January. DraftKings offers the best Denver Nuggets odds for the home team to cover the spread at -110.
  • The Philadelphia 76ers beat the Denver Nuggets in three of their past five encounters. DraftKings has the 76ers to cover the spread at -110.
  • The over total hit in three of the past five regular-season meetings between the Denver Nuggets and the Philadelphia 76ers. The best Denver Nuggets vs Philadelphia 76ers odds for the over total are available on DraftKings at -110.

Why will the Denver Nuggets cover the spread?

Whether by design or accident, the Denver Nuggets have seemingly found the winning formula going 8-3 (win-loss) to start the new year and that could continue as they take on the struggling Philadelphia 76ers next.

Denver heads into this matchup with Philadelphia as the moderate favorites and rightly so, considering the level of play they have shown in the past few games, particularly in their last assignment versus the Orlando Magic.

  • The Nuggets used a total team effort that saw five players hit double digits to beat the Magic 113-100 on Sunday but even more impressive is their work on the boards as they out-rebounded the latter 57-40.
  • Versatile big man Nikola Jokic delivered another triple-double performance, recording 20 points, 14 rebounds, and 10 assists on top of three steals and three blocks while bruising guard Christian Braun added a double-double of 20 points and 10 rebounds.

With the 76ers missing its franchise superstar Joel Embiid and some of its key players in this game, backing the Nuggets to cover the spread and possibly pull off a blowout win might be on the cards here.

  • It is also worth noting that Denver has been incredibly dominant in 2025, beating teams by double digits and by an average margin of 16.9 points.

One thing we’d like to see the Nuggets improve here though is their three-point shooting percentage. Against the Magic on Sunday, Denver only shot a dismal 28% from rainbow country.

Should the Nuggets address their three-point shooting woes, backing them to cover the spread and pull off another double-digit victory at -110 is something worth a punt considering how they have been performing in the past few games.

Why will the Philadelphia 76ers cover the spread?

Injuries continue to hound the Philadelphia 76ers as they dropped its sixth game in a row after losing to the Milwaukee Bucks on Sunday.

A tough test awaits the 76ers next as they end their three-game road trip versus the red-hot Denver Nuggets but amidst the flak they have been getting, backing them to cover the spread might be worth a look.

  • For one, Philadelphia played sound defense versus the Bucks, recording four steals and four blocks but even more remarkable was the fact that they only turned the ball over seven times.
  • Do-it-all guard Tyrese Maxey had 37 points against the Bucks but the 76ers will be glad to know that forward Paul George, who has been averaging 17.2 points, 5.9 rebounds, and 4.7 assists, is expected to play versus the Nuggets.
  • Speaking of the 76ers hard-knows defense, the team also ranks among the best as far as opponents points are concerned, allowing just 111.3 points per game.

With George’s expected return, Philadelphia gets another offensive weapon and that could play a significant factor in covering the spread versus the Nuggets who have been playing a notch over everyone in 2025.

For the 76ers to cover the spread, however, they will need everyone to step up, particularly their bench who was non-existent versus the Bucks with their reserves only pouring in 20 total points.

Should Philadelphia get offensive production from everyone to back-stop Maxey’s current scoring run, picking them to not only cover the spread but also potentially win outright is worth a shot at these current odds.

Final Denver Nuggets vs Philadelphia 76ers NBA Prediction: Denver Nuggets -12 (-110)

Healthy and at its best, the Philadelphia 76ers certainly have the talent to compete with the best teams in the league. Unfortunately, the 76ers are nursing with plenty of injuries and are far from healthy.

With the Denver Nuggets in much better shape and enjoying a hot January, I am confident in picking three-time MVP Nikola Jokic and the home squad to cover the spread and pull off another blowout win. Give me the Nuggets to cover the spread at -110.

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