NFL Best Bets For Tonight's TNF (December 4): Cowboys vs Lions Betting Odds & Player Prop Bets

NFL week 14 has arrived, and there's a Thursday night showdown between the Cowboys and Lions!

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Set to take place in the Motor City, the Dallas Cowboys (6-5, 2-4 away) will square off against the Detroit Lions (7-5, 4-2 home). Lucky for us, we get to watch both teams face off for two consecutive Thursdays!

Thanksgiving week was for the books, as both the Cowboys and Lions headline the holiday weekend. Riding a three-game win streak, Dallas knocked off Patrick Mahomes and the Kansas City Chiefs 31-28 on Thanksgiving Day. With the ability to overcome a fourth-quarter deficit, it was Dak Prescott's heroics that saved the day.

Finishing with two touchdowns and 320 passing yards, Prescott connected with receivers CeeDee Lamb and George Pickens for a combined 200 receiving yards! Not to mention Brandon Aubrey continues to showcase why he's the most elite kicker in the NFL.

The Lions are a Thanksgiving staple, although they dropped last week's matchup to division rival Green Bay Packers, 31-24. It's been a challenging time for Dan Campbell and company, who continue to face critical injuries.

Star receiver Amon-Ra St. Brown left last week's game with an ankle injury and remains questionable tonight. In addition, they lost Sam Laporta for the season, and now backup tight end Brock Wight will miss another week.  With several members of the offensive line questionable (Taylor Decker, Kayode Awosika, Graham Glasgow, Penei Sewell), how will the offense look for Jared Goff on Thursday night?

NFC Playoff Battle: Dallas Cowboys vs Detroit Lions

Tonight is a crucial matchup for both squads, as the Cowboys and Lions continue to fight for playoff spots. At 7-5, the Lions sit third in the NFC North, and with a 6-5 record, the Cowboys trail the Eagles for the top spot in the NFL East.

With the Bears, Rams, Eagles, Buccaneers, Seahawks, and Packers holding down NFC playoff spots, it's a must-win for Dallas and Detroit tonight. Per the NFL, the Lions have a 55 % chance of making the playoffs if they win tonight. If the Cowboys come out victorious, they'll have a 38 % chance.

Tonight, the stakes are high, and the Lions and Cowboys boast two of the most dynamic offenses in the NFL. A battle for the last NFC wild card spot, tonight should be a blood bath. Will the Lions overcome their injury woes, or will Dallas get their fourth straight road win?

Odds Are Current As Of December 4 AT 11 A.M. ET

If you're looking to bet on the Cowboys vs. Lions game, welcome!

Up over 3.9 units betting on the NFL, November was a strong month! Let's continue that in December, heading into the holidays!

Tonight's matchup will kick off at 8:15 p.m. at Ford Field, located in Detroit, Michigan.  Featuring top quarterbacks, such as Dak Prescott and Jared Goff, the showdown will air on Amazon Prime Video.

In this article, you will find a mix of wide receiver and total bets. Here are my three best bets and player prop picks for the Thursday, Dec. 4 NFL matchup featuring the Cowboys and Lions! I've placed all of my bets as separate picks within Fanatics, FanDuel, and DraftKings Sportsbook.

Are you in search of further NFL and sports betting promotions? We have compiled a list of the best sports betting offers here. 

NFL WEEK 14 BETS: Dallas Cowboys vs Detroit Lions FanDuel Odds For December 4

MONEYLINE

• DALLAS COWBOYS: +134
• DETROIT LIONS: -158

SPREAD

• DALLAS COWBOYS: +3 (-110)
• DETROIT LIONS: -3 (-110)

OVER/UNDER (TOTAL)

• OVER: 54.5 (-105)
• UNDER: 54.5 (-115)

BEST ODDS FOR DALLAS COWBOYS VS DETROIT LIONS

• BetMGM has the best odds, favoring the Detroit Lions  by three points (-110)
• The Dallas Cowboys will get their seventh home game this NFL season.  BetMGM offers the best odds at +100, tabbing the Cowboys as three-point spread underdogs.
• Caesars and BetMGM currently offer the best odds for the game totals. BetMGM offers the best value for the under (54.5) at -110, while Caesars offers the best value for the over (54.5) at -105 odds.

 Dallas Cowboys vs Detroit Lions Injury Report

COWBOYS

1. Tyler Guyton, LT: OUT
2. Malik Hooker, FS: QUESTIONABLE
3. Jadeveon Clowney, DE: QUESTIONABLE
4. Josh Butler, SS: OUT
5. Juanyeh Thomas, FS: OUT

LIONS

1. Amon-Ra St. Brown, WR: QUESTIONABLE
2. Kalif Raymond, WR: OUT
3. Brock Wright, TE: OUT
4. Kerby Joseph, FS: OUT
5. Brian Branch, SS: QUESTIONABLE
6. Taylor Decker, LT: QUESTIONABLE
7. Graham Glasgow, C: QUESTIONABLE
8. Penei Sewell, RT: QUESTIONABLE

NFL Predictions for Thursday, December 4, Week 14: Cowboys vs Lions

NFL Player Prop Bets Tonight: Jameson Williams

2025-2026 Season Stats

GP: 12  | REC: 38 | Targets: 63 | Receiving Yards: 706 | AVG: 18.6 | TD: 6  | Rec. Long: 64

• OVER 28.5 Longest Reception (-110 Fanatics)

My first best bet for Thursday night, I placed one unit on Lions receiver Jameson Williams to record over a 28.5 longest reception.

This is one of the strongest bets for the day. Now in his fourth season with the Lions, Williams appears to have overcome off-field issues. On pace for a second consecutive 1000-yard season, he may be Jared Goff's top option tonight.

Leading receiver Amon-Ra St. Brown left Thanksgiving early with an ankle injury and is questionable to lace up.  With Sam LaPorta out for the season, it leaves the door wide open for Williams.

While tonight may be an Isaac TeSslaa break-out game, Williams is one of the most elite deep threats in the NFL.

Second on the Lions in targets this season (63), Williams has established himself as one of Goff's top options. Averaging 18.6 yards per reception, he ranks in the top eight in the NFL in YAC (331). Not to mention he sits second behind Jaxon Smith-Njibba with 14 20+ receptions, and five 40+ receptions.

Jameson Williams WR1 if Amon-Ra St. Brown is out!?

In other words, I'm betting on Jameson to make some big plays down the field tonight. The Lions boast the sixth-best offense in the NFL, and rank in the top 10 in passing DVOA. If St. Brown is unable to suit up, Williams should have his way with either Shavon Revel or DaRon Bland.

We are talking about a player who's recorded north of 300 receiving yards after the catch in the left and right outside. Not to mention, Williams is averaging 8.8 YAC alone and hauling in 34.1 % of the team's air yards. Make no mistake, this guy is a human highlight reel.

This is a prime matchup for Williams, who faces a Cowboys defense that ranks No.31 in defensive DVOA. While they've been hot, we are talking about a secondary that gives up the second-most receiving yards to wideouts. And honestly, this is perfect for a player who averages a 26.6 longest reception per game!

On Thanksgiving, we saw Rashee Rice (Chiefs) explode for the longest reception of 28 yards. In addition, Malik Nabers (Giants) torched the defense for a 35-yard bomb, Garrett Wilson (Jets) for 25 yards, and Jaylin Lane (Commanders) for a 35-yard reception.

Final Cowboys vs Lions NFL betting prediction: Jameson Williams OVER 28.5 Longest Reception (-110 Fanatics)

Let's face it—Williams has cleared this player prop line in four of the last five games, and last caught 63 and 37-yard receptions against the Cowboys. Given Dallas has improved against the run as of late, Goff and the passing game should feast here.

• I'm taking Jameson Williams to haul in over a 28.5 longest reception tonight. He's coming off a season-high 144 receiving yards on 10 targets and seven receptions against the Packers. Averaging a longest reception of 32.5 yards over the last five games, look for Williams to build on last week. In fact, he led all receivers in Detroit with a 94 % snap count last week.

NFL Player Prop Bets Tonight: George Pickens

2025-2026 Season Stats

GP: 12  | REC: 73 | Targets: 105 | Receiving Yards: 1,142 | AVG: 15.6 | TD: 8 | Rec. Long: 45

• OVER 5.5 Receptions (-122 FanDuel)

My second-best bet for tonight, I placed one unit on Cowboys receiver George Pickens to record over 5.5 receptions.

Traded from the Steelers to the Cowboys, Pickens is having a career year in the Lone Star State. A 1-2 punch with CeeDee Lamb, Pickens has become one of Dak Prescott's most reliable and trustworthy receivers.

Broken curfew in Vegas or not—Pickens isn't letting off-the-field drama affect his game.  Tied second with 1,142 receiving yards, Pickens is in the top seven in receptions (73) and third in touchdowns (8). By trading him, he's completely unleashed his potential following his split from Mike Tomlin and company.

Why George Pickens Can Soar Over This Player Prop Tonight

While Lamb is the No.1 wideout, he's been hampered by injuries. In his absence, Pickens has emerged as the leader in receptions (73), targets (105), and receiving yards (1,142) for the Cowboys.

We've already seen him explode for a career-high 146 receiving yards against the Raiders. Posting back-to-back 140+ receiving yards, Pickens has tallied 33 targets, 24 receptions, and 378 receiving yards over the last two games!

We already know the Cowboys' offense heavily relies on Pickens, Lamb, and Jake Ferguson in the receiving game. With Pickens and Lamb playing 74 and 81 % of snaps last week, there's little competition for receptions and targets.

Overall, Pickens is a significant part of the Cowboys' success and their exploding offense amid a massive win streak. Ranked No. 9 in offensive DVOA, the Cowboys remain in the top ten in the passing game.

Final Cowboys vs Lions NFL betting prediction: George Pickens OVER 5.5 Receptions (-122 FanDuel)

I'm confident in this player prop, especially given Pickens is hauling in 24.1% of team targets and is targeted nearly 25% on routes. Most likely set to set up shop opposite of D.J. Reed, the cornerback has allowed over 16 receptions this season.

• I'm taking George Pickens to record over 5.5 receptions Thursday night. He should feast against a banged-up Lions secondary, which allows 11.2 receptions to wide receivers per game. Recently, we saw Dontayvion Wicks (Packers) and A.J. Brown (7) haul in well over 5.5 receptions. Currently, Pickens ranks in the top five among NFL receivers in total receptions (73) and sixth in routes run (440). Expect a big game between Prescott and Pickens tonight, especially if Branch is out tonight.

NFL Total Bet Tonight: Dallas Cowboys vs Detroit Lions

• Cowboys vs Lions OVER 53.5 Total Points (-125 DraftKings)

My third-best bet for today, I placed one unit on the Cowboys vs. Lions game to record over 53.5 total points.

Tonight features two of the most potent offenses, and the Cowboys and Lions boast a combined 15-9 over/under record this season. Both ranking in the top ten in offensive DVOA, the Cowboys (393.1 yards per game) and Lions (376.3) rank in the top three in total yards per game.

It's all about the offense between these two teams. I mean, we are talking about two teams that combined for an average of 58.5 yards per game!

I doubt the same outcome will result tonight; however, the Lions last defeated the Cowboys 47-9 in November 2024. Aforementioned, the Lions rank among the top ten in defensive DVOA, but there are several question marks and injuries.

I mean, are we really going to fade a team that thrives on fourth-down conversions and attempts? Soaring over 53.5 points in three of the last five games, the Lions have given up an average of 24 points over the last four games. In fact, they've allowed 27+ points in back-to-back games against the Packers and Giants.

For Dallas, the offense is firing on all cylinders, and we've seen the Cowboys put up 30+ points in two of the last three games.

Call them the comeback kids, but putting 31 points against the Chiefs on Christmas Day is impressive.

There's no question that 53.5 total points is an extremely high number, and I do believe the outcome will be close here. We've seen the Cowboys improve drastically on defense, but will it be enough tonight? If this soars under, we'll have to take a look at a banged-up Lions offense line against a new and improved Cowboys d-line. Let's not forget the Cowboys acquired Quinnen Williams as part of the Micah Parsons trade.

Final Cowboys vs Lions NFL betting prediction: Cowboys vs Lions OVER 53.5 Total Points (-125 DraftKings)

Given that both the Cowboys and Lions score over 60 % in the red zone, both are north of 50 % on 4th down conversions.

• I'm taking the over tonight. While the Cowboys' defense has surged from the basement, I simply can't fade two top offenses. Both Dak Prescott and Jared Goff rank in the top ten in Total EPA and pass EPA. Three of the last six Thursday matchups, including Thanksgiving, have cleared over 50 total points alone.