NFL Best Bets For Tonight's TNF (September 25): Seahawks vs Cardinals Betting Odds & Player Prop Bets

Thursday night football is here, and there's a highly anticipated matchup featuring the Seahawks and Cardinals.

The first matchup of NFL week 4, the Arizona Cardinals (2-1, 1-0 home) will host the Seattle Seahawks (2-1, 1-0 away) at home. Tonight's showdown features two NFC West division rivals. Both 2-1 on the season, both teams trail the San Fransisco 49ers for first place.

The first meeting between the two teams since December 2024, the Seahawks and Cardinals met three times last season. In fact, the Seahawks are 8-2 in their last 10 head-to-head matchups, and 7-0 in their last seven outings. The Cardinals had a decent offseason, re-signing star tight end Trey McBride, and the additions of Josh Sweat, Baron Browning, and Dalvin Tomlinson. Although doubtful, Will Johnson was a decent pick in the 2025 NFL Draft at corner.

The Cardinals are +108 moneyline underdogs at home, and have two victories over the Carolina Panthers and New Orleans Saints, two sub .500 teams. Losing to the 49ers by just one point in week 3, Arizona looks to bounce back on Thursday.

Seattle had an interesting offseason, bringing in quarterback Sam Darnold to replace Geno Smith. Although the team traded wideout DK Metcalf to the Steelers, the Seahawks signed receiver Cooper Kupp in free agency. While they upgraded their offensive line by selecting Grey Zabel in the NFL Draft, they doubled down at the quarterback position by selecting Jalen Milroe.

The Seahawks have had an impressive 2025-2026 campaign, earning victories over the Pittsburgh Steelers and New Orleans Saints. More impressive, they boast one of the strongest defenses in the NFL (so far). Allowing the second-fewest points per game (15.7), Seattle and Arizona have been one of the top teams in the red zone defensively.

NFC West Divisional Matchup: Seahawks vs Cardinals

While Arizona has home field advantage tonight, the Seahawks are 4-0 on the road since 2022 when playing the Cardinals.

Seattle's starters are mainly healthy, aside from guard Anthony Bradford  and linebacker Boye Mafe, whom are both questionable. In addition, running back Zach Charbonnet is questionable after missing last week's matchup.

For Arizona, several starting offensive linemen are questionable, including Paris Johnson Jr., Evan Brown, and Zay Jones. In addition, Akeem Davis-Gaither and Will Johnson or questionable and doubtful on the defensive line.

Both teams aren't highly favored to raise the Vince Lombardy Trophy. The Seattle Seahawks have +5000 odds while the Cardinals have +5500 odds to win the Super Bowl.

Odds Are Current As Of September 25 AT 12 P.M. ET

If you're betting on the NFL, and Thursday Night Football (TNF), welcome!

Kickoff for Thursday's matchup will begin 8:15 p.m. ET, and will broadcast on Amazon Prime Video. According to the weather forecast, winds are projected at 10.3 mph at the start of the game, although State Farm Stadium has a retractable roof.

With a 47-23 NFL betting record, I am up over 14 units betting on football this month! Be sure to follow all my bets in the Ballislife Discord, and the Pikkit app.

In this article you will find a mix of total bets, and player prop picks including star tight ends, quarterbacks, and team bets. It's important to note I placed all my bets as separate picks within FanDuel Sportsbook.

Let's take a deeper dive at my three best bets, total picks, player prop bets, and predictions for the Thursday, September 25 NFL week 4 matchup featuring the Seattle Seahawks and Arizona Cardinals!

Are you in search of further NFL and sports betting promotions? We have compiled a list of the best sports betting offers here. 

NFL WEEK 4 BETS: Seattle Seahawks vs Arizona Cardinals FanDuel Odds For September 25

MONEYLINE

• SEATTLE SEAHAWKS: -126
• ARIZONA CARDINALS: +108

SPREAD

• SEATTLE SEAHAWKS: -1.5 (-110)
• ARIZONA CARDINALS: +1.5 (-110)

OVER/UNDER (TOTAL)

• OVER: 43.5 (-105)
• UNDER: 43.5 (-115)

BEST ODDS FOR SEATTLE SEAHAWKS VS ARIZONA CARDINALS

• BetMGM has the best odds, favoring the Seattle Seahawks by 1.5 points (-105)
• The Arizona Cardinals will get their second home matchup this NFL season.  BetMGM offers the best odds at -105, tabbing the Cardinals as +1.5- point underdogs.
• BetMGM and FanDuel Sportsbook currently offer the best odds for the game totals. BetMGM offers the best value for the under (43.5) at -110, while FanDuel offers the best value for the over (43.5) at -105 odds.

Seattle Seahawks vs Arizona Cardinals Injury Report

SEAHAWKS

1. Anthony Bradford, RG: Questionable
2. Zach Charbonnet: RB: Questionable
3. Boye Mafe, LB: Questionable
4. Josh Jones, RT: OUT
5. Jonathan Hankins, NT: OUT

CARDINALS

1. Evan Brown, LG: Questionable
2. Akeem Davis-Gaither, LB: Questionable
3. Paris Johnson Jr., LT: Questionable
4. Zay Jones, WR: OUT
5. Will Johnson, CB: Doubtful

NFL Predictions for Thursday, September 25 Week 4: Seahawks vs Cardinals

NFL Player Prop Bets Tonight: Trey McBride

2025-2026 Season Stats

GP: 3  | Receptions: 17 | Targets: 24 | Receiving Yards: 182 | Avg: 10.7 | Rec TD: 1| Rush TD: 1 | Long Rec: 31 | First Down: 10

• OVER 19.5 Longest Reception (-118 FanDuel)

My first best bet for today, I placed one unit on Arizona Cardinals star tight end Trey McBride to record over 19.5 longest reception against the Seattle Seahawks.

In case you missed it, I bet on McBride to score a touchdown in my previous article. While Marvin Harrison Jr. is the No. 1 wideout, it's been McBride who's been Kyler Murray's top receiving option.

Not only does McBride lead the Cardinals in targets (24), receiving yards (182), and receptions (17), and has a longest reception of 31 yards against the Carolina Panthers. This season he's hauled in a 25-yard reception against the New Orleans Saints, and 17-yard gain against the 49ers.

Why Trey McBride Can Soar Over This Player Prop Bet

Thursday should be a massive game for McBride, given the Seahawks allow the seventh most yards to tight ends per game (60). In addition, Saints tight end Juwan Johnson pulled in a 21 longest reception in week 3.

McBride is an elite tight end who is truly a 3-level threat on the field. Similar to a receiver, he can get down field and make the highlight plays. While the Seahawks have a solid defensive line in Mafe, Bryon Murphy II, Leonard Williams, and DeMarcus Lawrence, I don't trust their linebacker core. Plus, they have injuries.

Combine McBride's talent along with the fact the Seahawks' allow a longest reception average of 31.3 yards this season. Recording 97 percent snaps in week 1, 91 percent in week 2, and 88 percent in week 3, his snap count is more than just okay. Out targeting Harrison Jr. by a mile, tonight may be his night.

Final Seahawks vs Cardinals NFL betting prediction: Trey McBride OVER 19.5 Longest Reception (-118 FanDuel)

Not only is James Connor out for the season, the Cardinals may decide to pass more. After all, they run 61.6 percent of pass plays compared to 37.4 percent run plays under Drew Petzing.

Overall, I was impressed with McBride, who recorded 43 yards against a tough 49ers defense.  Over the last three games, he's impressed with nine, seven, and eight targets. Through three weeks, he's averaging anywhere between five and six receptions.

• I'm taking Trey McBride to record over 19.5 longest reception. Soaring over this prop line in two of the last three head-to-head matchups, he's cleared this line in four of five games dating back to last season. Seattle has been forgiving to tight ends, and allow the sixth most receiving yards to that position. 

NFL Player Prop Bets Tonight: Kyler Murray

2025-2026 Season Stats

GP: 3  | CMP: 60 | Attempts: 89 | CMP: 67.4 % | Passing Yards: 542| Passing TD: 4 | Pass Long:45 | Rushing Yards: 107 | Rushing TD: 0 | Interceptions: 1

• OVER 21.5 Completions (-102 FanDuel)

My second best bet for tonight, I placed one unit on Arizona Cardinals quarterback Kyler Murray to record over 21.5 completions against the Seattle Seahawks.

Murray has had a fairly decent season so far, compiling 542 passing yards, four touchdowns, and one interception. Notorious for utilizing the chains to use his legs, I'm betting on him to throw the ball tonight.

That's if Marvin Harrison Jr. can improve on drops. Last week, he was left wide open and dropped a critical pass.

This year, we've seen Murray put up 29, 25, and 39 attempts against the Saints, Panthers, and 49ers. Last week, we saw an increase in both completions (22), and attempts (35) against a stingy San Fransisco defense.

Is Kyler Murray The Cardinals' Quarterback Of The Future?

While the Seahawks only allow 15.4 points per game, they allow the fifth most completions (24.7), and sixth highest passing attempts (37) to quarterbacks.

Aforementioned, the Cardinals lost running back James Connor due to an achilles injury. Although they have have a running back committee of Trey Benson and Emari Demercado, I'm expecting the Cardinals to air the ball out tonight.

At home with a retractable roof? Why not. The Seahawks allow 221.7 passing yards per game, and Brock Purdy (277), Aaron Rodgers (203), and Spencer Rattler (218) all clear 200 passing yards.  In addition, both Rattler and Purdy recorded 28 and 26 completions.

Since 2022, Murray has soared over this prop line, clearing the completion pass rate in six straight head-to-head matchups against the Seahawks. Averaging 24.5 pass completions over that span, I'm confident in this bet tonight.

Final Seahawks vs Cardinals NFL betting prediction: Kyler Murray OVER 21.5 Completions (-102 FanDuel)

Overall, Murray shouldn't have a hard time tonight given the Seahawks rank No. 14 in success rate, and No. 17 in dropback EPA. Plus, over the last six matchups against Seattle, he's averaged 36 passing attempts per game.

• I'm taking Kyler Murray to record over 21.5 completions today for -102 odds. There's great value there at nearly plus money. 

NFL Player Total Bets Tonight: Seahawks vs Cardinals

• Seattle Seahawks vs Arizona Cardinals UNDER 43.5 Points (-115 FanDuel)

My third best bet for today, I placed one unit on the Seahawks vs Cardinals matchup to total under 43.5 points.

Surprisingly, both teams have been in the top defensive rankings this season. Ranking No. 2 in opponent points per game (15.7), the Seahawks allow well under 20 points per game. For the Cardinals, they rank No. 5 in opponent points per game (17).

With that said, Seattle has soared under just once, scoring 44 and 31 points against the Saints and Steelers. Meanwhile, Arizona has cleared the under twice.

Although both Thursday night games cleared this point total this season, I think 43.5 points has great value here. The Cardinals rank 11th in offensive DVOA, yet face a Seahawks team thats scary. While this Cardinals team has improved much this season, can they keep up with a Seattle team that's mainly healthy and loves to run the ball.

Final Seahawks vs Cardinals NFL betting prediction: UNDER 43.5 Points (-115 FanDuel)

Even possibly without Charbonnet, the Seahawks rank No. 12 in rushing DVOA, and I do have concerns about Arizona's offense against a stingy defense.  How will their run game fare without James Connor? Seattle has been elite in the defending the run game, so this may force Murray to pass more.  Will Murray finally be able to connect with Harrison Jr. without drops? Trey McBride seems to be the only reliable option for Murray.

• I'm taking the under on this one tonight and trusting the defenses.