Seahawks vs Cardinals Anytime Touchdown Scorer Predictions: NFL Best Bets for Thursday, September 25

NFL week 4 is here, and there's a highly anticipated Thursday night matchup ahead featuring the Cardinals and Seahawks!

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In an NFC West divisional showdown, Kyler Murray and the Arizona Cardinals (2-1, 1- home) will host Sam Darnold and the Seattle Seahawks (2-1, 1-0 away).

The books are predicting a close game, as the Seahawks are tabbed as a -1.5-point favorite on the road. While the San Francisco 49ers lead the division at 3-0, the Cardinals and Seahawks aren't far back with a 2-1 record.

Seattle has new pieces to its roster, including quarterback Sam Darnold and wide receiver Cooper Kupp. It's easy to see why they are the favorites, given they are 7-0 against Arizona in their last seven outings and 8-2 in the previous 10 matchups.

In week 3, the Seahawks dominated the New Orleans Saints 44-13, in which Sam Darnold threw for 218 yards and two touchdowns. The week prior, Seattle torched Aaron Rodgers and the Pittsburgh Steelers 31-17.

Although the Cardinals lost a nail-biter to the 49ers last week, 16-15, they have two victories over the Carolina Panthers and Saints.

Both teams have several players listed on the injury report for Thursday. Arizona has multiple players questionable on their offensive line, as well as on the defense. With James Connor ruled out for the season with an Achilles injury, Trey Benson and Emari Demercado will take over the backfield. For Seattle, there are injuries on both sides of the ball.

Let's take a look at my three best bets predicting who will score a touchdown featuring the Seattle Seahawks vs the Arizona Cardinals on Thursday, September 25! Let's start NFL week 4 strong!

All of my bets in this article were made separately within FanDuel Sportsbook.

NFL Week 4 Best Bets: Seahawks vs Cardinals Anytime Touchdown Scorer Predictions for Thursday, September 25

Kenneth Walker III Anytime TD Odds: +110 (FanDuel)

2025-2026 NFL Stats

GP: 3  | Carries: 39 | Rushing Yards: 163 | Avg Rushing: 4.2 | Rush TD: 3 | Rec TD: 0 | Rush Long: 20| First Down: 11

My first best bet for Thursday, I placed one unit on Seattle Seahawks running back Kenneth Walker III to score a touchdown against the Arizona Cardinals.

Zach Charbonnet was a full participant on Monday with a foot injury, and Seahawks head coach Mike Macdonald has continued to deploy a running back committee with the two.

Either way, Walker showed why he's more than capable of handling goal-line and lead-back duties. With Charbonnet out in the last game, Walker recorded 38 yards on 16 carries. It was his two rushing touchdowns that saved his betting and fantasy football owners.

This season, Walker leads the pack in rushing yards (163) and three rushing touchdowns. Through the first three weeks, his efficiency has been up and down; however, we saw him explode for 105 rushing yards and a touchdown against the Steelers in Week 2.

Why Kenneth Walker III Can Score A Touchdown Thursday Night

Until week 3, it was Charbonnet who outsnapped Walker by 38 percent in the first two weeks. For Walker, he played 40 percent of snaps in week 1, 35 percent in week 2, and increased to 53 percent without Charbonnet in week 3.

Although the Cardinals have a weaker schedule to start the season, they boast one of the best defenses in the league. Allowing just 17 points per game, they are giving up the fourth fewest rushing yards per game (76.3). In fact, they've given up just one rushing touchdown the entire year to Alvin Kamara.

Either way, I'm riding with Walker tonight. With three rushing touchdowns over the last two weeks, he's been the superior goal-line back. This season, he's rushed for 41 yards on nine attempts for three touchdowns inside the 20. Compare that to Charbonnet, who's rushed for 10 yards on six attempts for one rushing touchdown.

The Cardinals have strong defensive players in Calais Campbell and Josh Sweat; however, there are some question marks in the middle of that defensive line. Arizona is limiting opponents to 41.67 percent in the red zone, and even ranks No. 6 in rush EPA.

Final NFL Anytime Touchdown Seahawks vs Cardinals Betting Prediction: Kenneth Walker III ATS Odds: +110 (FanDuel)

Luckily for Seattle, they've been one of the more efficient teams inside the 20, scoring at a 63.64 percent rate in the red zone. No. 12 in EPA/rush (0.12), Walker

• I'm taking Kenneth Walker III to score a touchdown Thursday. While the backfield could remain split 50/50, Walker is the more explosive back who can break tackles. It would be even better if Charles Cross, Grey Zabel, and Abraham Lucas could hold up that offensive line. 

Trey McBride Anytime TD Odds: +165 (FanDuel)

2025-2026 NFL Stats

GP: 3  | Receptions: 17 | Targets: 24 | Receiving Yards: 182 | Avg: 10.7 | Rec TD: 1| Rush TD: 1 | Long Rec: 31 | First Down: 10

My second-best bet for Thursday, I placed one unit on Arizona Cardinals star tight end Trey McBride to score a touchdown against the Seattle Seahawks.

Considered one of the most elite tight ends in the game, McBride has easily one of the best matchups of the year. Although Seattle boasts one of the best defenses in the NFL, it's allowed three touchdowns to tight ends this year. In addition, they give up the eighth most receiving yards to tight ends per game (60).

Since the Seahawks give up the second-most touchdowns to tight ends, I like McBride in this spot. With just one rushing and receiving touchdown, he found the endzone against the 49ers last week.

Is Trey McBride The Best Tight End In The NFL?

Yet to fully explode, he's compiled 182 receiving yards, including 61 and 78 against the Saints and Panthers. Now he gets a Seahawks' defense that allows 1.3 passing touchdowns per game.

This season, Seattle has given up touchdowns to George Kittle (49ers), Tyler Higbee (Rams), and Jake Tonges (49ers).

Plus, McBride is Kyler Murray's top target, leading the Cardinals in receiving yards (182), targets (24), and receptions (17). That ranks him above wide receivers Marvin Harrison Jr. and Michael Wilson.

Overall, McBride is the clear No.1 tight end, playing 97 percent of snaps in week 1, 91 percent in week 2, and 88 percent in week 3. Plus, Murray faces a Seattle team that ranks No. 17 in dropback EPA and No. 14 in success rate.

Final NFL Anytime Touchdown Seahawks vs Cardinals Betting Prediction: Trey McBride ATS Odds: +165 (FanDuel)

Aside from Brock Bowers, McBride plays similarly to a tight end and is one of the best route-running tight ends in the NFL. Plus, he truly is a 3-level threat on the field. Now that James Connor is out for the season,  I still see the Cardinals running the ball. However, there may be increased production for McBride.

• I'm taking Trey McBride to score a touchdown vs the Seahawks Thursday (TNF). He's primed for a big game and is targeted by Murray 60 percent in the red zone this season. 

Jaxon Smith-Njigba Anytime TD Odds: +160 (FanDuel)

2025-2026 NFL Stats

GP: 3  | Receptions: 22 | Targets: 29 | Receiving Yards: 323 | Avg: 14.7 | Rec TD: 1 | Rush TD: 0 | Long Rec: 45 | First Down: 14

My third best bet for Thursday, I placed one unit on Seattle Seahawks wide receiver Jaxson Smith-Njigba to score a touchdown against the Arizona Cardinals.

In his third season with the Seahawks, Smith-Njigba has emerged as Darold's top receiver. While the Seahawks acquired Cooper Kupp in the offseason, Smith-Njigba leads Seattle in receptions (22), targets (29), yards (323), and average yards per catch (14.7).

Although recording just one touchdown on the season, he ranks second behind Puka Nacua in receiving yards. Not to mention he's in the top four in receptions.

This season, Smith-Njigba has played 77 percent of snaps in week 1, 65 percent in week 2, and 49 percent in week 3. Although dealing with an illness last week, he found the endzone for 96 yards against the Saints.

On Thursday, he faces a Cardinals team that may be without linebacker Akeem Davis-Gaither and cornerback Will Johnson. Arizona already gives up the sixth most receiving yards per game to wideouts (164.7) and two touchdowns this season.

Although Arizona has yet to give up a touchdown to WR1s, we've seen Ricky Pearsall crossed the plane against them this season. Through week 3, Arizona ranks No. 26 in defensive success rate and No. 13 in dropback EPA.

Final NFL Anytime Touchdown Seahawks vs Cardinals Betting Prediction: Jaxson Smith-Njigba ATS Odds: +160 (FanDuel)

Overall, Njigba should have a fairly decent matchup against Denzel Burke and Jalen Thompson. With the departure of Tyler Lockett and DK Metcalf, he's lined up more in the wide than the slot (in large part to Kupp). Given that Arizona allows 1.3 passing touchdowns per game, I love Smith-Njigba in this spot.

• So far, he has a 50 percent target rate inside the 20 with a touchdown.  With 28 targets through three weeks, the Cardinals have the fifth-most receiving yards to wideouts. I'm taking Jaxon Smith-Njigba to score a touchdown Thursday. We saw how well the Panthers performed, going 3-4 in the red zone against Arizona in Week 2.  The Cardinals have already lost cornerbacks Garrett Williams and Joey Blount. I'm expecting a big passing night from Darnold.