NFL Week 12 Anytime Touchdown Scorer Predictions: Best Bets for Sunday, November 23

NFL week 12 is here, so let's discuss who's scoring a touchdown on Sunday!

(Photo by Brooke Sutton/Getty Images)

We are more than halfway through the 2025-2026 NFL season, and there's a massive 12-game slate to bet on this week! Let's take a look at a few of the top matchups and storylines for Sunday.

Aaron Rodgers and the Pittsburgh Steelers (6-4) will face Caleb Williams and the Chicago Bears (7-3). With a 25-5 career record against the Bears, Rodgers isn't wrong when he says "he owns the Bears." This time, he faces a newly revamped Chicago team as a first-time member of the Steelers. With head coach Ben Johnson at the helm, the Bears are slim 2.5-point spread favorites at home.

A matchup in the NFC North, the Green Bay Packers (6-3) will host division rival Minnesota Vikings (4-6) at home. With the Bears atop the division, this is a crucial game for the Packers. While the Vikings have fallen behind amid injuries, this is a must-win for Green Bay. 1-3 against Minnesota since 2023, the Packers are favored among sportsbooks by 6.5 points.

Sunday afternoon, Patrick Mahomes and the Kansas City Chiefs will face Daniel Jones and the Indianapolis Colts (8-2). While no one saw it coming, the Colts are among the top teams in the AFC, although they are tabbed as 3.5-point spread underdogs on the road. At 5-5, this is a must-win for Kansas City, which is fresh off two straight losses against the Broncos and Bills.

NFL Week 12 Key Matchups

Sunday afternoon will feature top NFL East division rivals, the Philadelphia Eagles (8-2) and the Dallas Cowboys (4-5).  While the Eagles have seemingly claimed the division, the Cowboys aren't done yet. After Jerry Jones struck hot at the NFL trade deadline, the Cowboys are 3.5-point spread underdogs at home. In fact, Jalen Hurts and the Eagles defeated the Cowboys 24-20 in week 1.

Last, there's a highly-anticipated Sunday night matchup featuring the Tampa Bay Buccaneers (6-4) and the Los Angeles Rams (8-2). Two top four teams in the NFC, who doesn't love an elite quarterback matchup between Baker Mayfield and Matthew Stafford? Their first meeting since 2022, the stakes are high for both squads. However, the books are not predicting a close one, as the Rams are favored by 7 points at home.

In this article, you will find my three best bets and touchdown scorer predictions for the Sunday, Nov 23, matchups! Featuring top running backs, quarterbacks, and receivers, I placed all of my picks within Fanatics sportsbook. Since betting on touchdowns is an extremely risky play, I do emphasize responsible betting and bankroll management.

Are you in search of further NFL and sports betting promotions? We have compiled a list of the best sports betting offers here. 

NFL Week 12 Best Bets: Anytime Touchdown Scorer Predictions for Sunday, November 22

Jalen Hurts Anytime TD Odds: -115 (Fanatics)

2025-2026 NFL Stats

GP: 10 | CMP: 180 | Attempts: 269 | CMP: 66.9 % | Passing Yards: 1,995 | Passing TD: 16 | Pass Long: 79 | Rushing Yards:2 65 | Rushing TD: 6 | INT: 1

My first-best bet for Sunday, I placed one unit on Philadelphia Eagles quarterback Jalen Hurts to score a touchdown against the Dallas Cowboys.

I know this is a "corporate" or popular pick; however, I like this for several reasons, and there's still great value in this bet (-115).

We all know the Eagles are notorious for the "tush push," which doesn't seem to be going anywhere soon. With that said, they have one of the best offensive lines in football, although Lane Johnson will sit this one out.

With 22 touchdowns on the season, six of them have come on the ground, and two alone came against the Cowboys in week 1.

Why Jalen Hurts Can Score a Touchdown Against the Eagles on Sunday

Don't be alarmed—the three-game rushing touchdown drought is over. In fact, Hurts redeemed himself with a second-quarter goal-line touchdown against the Lions. In the Eagles' 16-9 victory over the Lions, it was Hurts who scored the lone touchdown!

While Hurts hasn't nearly run as much, he's still outperforming running back Saquon Barkley, who has just four touchdowns on the season. And while the Cowboys defense looked stellar last week, let's face it—they rank No. 31 in defensive DVOA. Equally as weak on both sides of the ball, they respectfully sit 3oth and 29th in defensive pass and rush DVOA.

Overall, this is a great matchup for Hurts, who faces a Cowboys defense that allows the 10th-most rushing touchdowns to quarterbacks. The Eagles went 3-3 (100 %) in red zone attempts against them in week 1!

Final NFL Anytime Touchdown Betting Prediction: Jalen Hurts ATS Odds: -115 (Fanatics)

Scoring two touchdowns over the last five games, Hurts has crossed the plane five times over the last four head-to-head matchups against the Cowboys. With 2+ rushing touchdowns against Dallas over their last two meetings, newly acquired Kenny Clark and Quinnen Williams will be awaiting his presence.

• I'm taking Jalen Hurts to score a touchdown on Sunday. Luckily for Hurts, the Eagles boast the highest (75 %) touchdown percentage in the red zone. In their favor, Dallas allows the fourth-highest touchdown percentage (66.7 %) amongst opponents inside the 20! While Barkley is a threat at the goal line, the Cowboys haven't allowed a touchdown to an RB1 since Sept. 28!

DK Metcalf Anytime TD Odds: +150 (Fanatics)

2025-2026 NFL Stats

GP: 10 | REC: 37 | TGTS: 62 | Receiving Yards: 551 |AVG: 14.9 | Touchdowns: 5 | Receiving Long: 80

My second-best bet for Sunday, I placed one unit on Pittsburgh Steelers wide receiver DK Metcalf to score a touchdown against the Chicago Bears.

If Aaron Rodgers knows any team, it's the Bears.  After playing 18 seasons with the Packers, what better way to return to the Windy City? Metcalf is the clear No. 1 receiver and has a prime opportunity to feast on Sunday.

Eclipsing 100+ receiving yards just once this season, Metcalf is having an underwhelming season in the Steel City.  Leading the Steelers in receiving yards (551), targets (62), receptions (37), and touchdowns (5), there's a lot of separation between Metcalf, Pat Freirmuth, and Calvin Austin III.

Is DK Metcalf Still Considered a WR1?

It's clear the Steelers aren't the most pass-efficient team (No. 24 passing DVOA); however, they face a Bears team that allows north of 231 passing yards per game! Ranking No. 26 in defensive DVOA, defense isn't Chicago's strong suit—they allow the fourth-MOST touchdowns to receivers!

Metcalf is in a three-week touchdown drought, and this is a Pittsburgh team that's allowed multiple touchdowns to Tee Higgins (Bengals) and Chris Olave (Saints) over the last five weeks! Over that span, every WR1 has topped 60+ receiving yards. As we know, Metcalf is one of the best deep ball threats in football.

Overall, there's not much competition for Metcalf. Playing 86 percent of snaps in week 11, he leads all wideouts with 518 snaps! Plus, he's averaging 21.6 % of team targets and putting up 41.7 % of team air yards. A freakish athlete, Metcalf remains one of the NFL's strongest receivers.

Final NFL Anytime Touchdown Betting Prediction: DJ Metcalf ATS Odds: +150 (Fanatics)

• I'm taking DK Metcalf to score a touchdown Sunday. He's been targeted six times in the red zone over the last five weeks and has been targeted 15 times in the last two games. While failing to soar over 60+ receiving yards over the last five weeks, he's been questionable as a viable WR1 in fantasy. Of course, this is all contingent on whether Aaron Rodgers plays. Even so, Metcalf has this matchup over cornerback Nahshon Wright. 

Travis Etienne Jr. Anytime TD Odds: -105 (Fanatics)

2025-2026 NFL Stats

GP: 1  | Carries: 12 | Rushing Yards: 39 | Avg Rushing: 3.3 | Rush TD: 5 | Rec TD: 1 | Rush Long: 12

My third-best bet for Sunday, I placed one unit on Jacksonville Jaguars running back Travis Etienne Jr. to score a touchdown against the Arizona Cardinals.

I'm still riding with Etienne Jr., who scored two rushing touchdowns against the LA Chargers last week. Am I worried about Bhayshul Tuten? Not really, and here's why.

There's no question that Liam Cohen is utilizing a running back committee. Last week, both Tuten and Etienne Jr. split the carries, each scoring a touchdown. While Etienne Jr. led the way with 19 carries, both backs rushed for 73+ yards each. It's understandable, given Etienne rushed for 58 yards on 16 carries in the Jags' 36-29 collapse against the Texans the week prior.

Will Travis Etienne Jr. Continue to Face Pressure From Bhayshul Tuten?

Even so, Etienne outsnapped Tuten 49 to 32 percent last week, and still leads the team in snap counts (405). However, his 49 % snap rate was the lowest all season.

This bet will be a tall task given the Cardinals' rank No. 11 in defensive DVOA. And to be honest, they've struggled against the run. If Etienne Jr. can maintain the lead duties, the Cardinals allow the 11th most touchdowns to running backs, and have been forgiving as of late!

Not only did Christian McCaffrey explode for three rushing touchdowns last week, but the Cardinals have given up six rushing touchdowns over the last four games! That includes Josh Jacobs (Packers), who finished with a multi-touchdown performance against Arizona on Oct. 19.

At 6-4, this is a more meaningful game for the Jaguars; the Cardinals have top players in Josh Sweat, Calais Campbell, and Zaven Collins on the defensive end.

Final NFL Anytime Touchdown Betting Prediction: Travis Etienne Jr. ATS Odds: -105 (Fanatics)

• Overall, I'm taking Travis Etienne Jr. to score a touchdown Sunday. Although suffering a shoulder injury, he appears good to go this week. Recording 15 carries last week, Tuten is certainly putting the pressure on. Let's not discount Etienne Jr., who has three touchdowns over the last three outings.