NFL Week 2 Anytime Touchdown Scorer Predictions: Best Bets for Sunday, September 14

NFL week 2 has arrived, and there's a full slate of games this Sunday!

(Photo by Brooke Sutton/Getty Images)

With nine 1 p.m. ET matchups, four 4 p.m. ET outings, and Sunday Night Football, there's plenty to bet on! In this article, I'll focus on my anytime touchdown scorer predictions for week 2!

Key NFL Matchups: Week 2

Sunday's slate highlights an NFC North rival matchup between the Chicago Bears (0-1, 0-0 away) and the Detroit Lions (0-1, 0-0 home). The rivalry has further strengthened now that former Lions Offensive Coordinator Ben Johnson is the current head coach of the Bears. 6.5-point spread underdogs, it's the first time Ben Johnson will face the Lions with the Bears.

Sunday's matchup will further feature AFC East rivals Buffalo Bills and New York Jets, along with NFC East enemies New York Giants and Dallas Cowboys. With Micah Parsons traded to the Green Bay Packers, the Cowboys are heavily favored (-245 moneyline) today. 1-9 against Dallas since 2020, will the Giants prevail under quarterback Russell Wilson?

Sunday's NFL slate further highlights an AFC North divisional matchup between Lamar Jackson's Baltimore Ravens, and Myles Garrett's Cleveland Browns. Under the Mike Vrabel era, Drake Maye and the New England Patriots will face AFC East rival Tua Tagovailoa and the Miami Dolphins.

Super Bowl LIV Rematch: Philadelphia Eagles vs Kansas City Chiefs

Arguably, the most highly anticipated showdown of week 2 will feature a Super Bowl LIX rematch between the Philadelphia Eagles (1-0, 0-0 away) and the Kansas City Chiefs (0-1, 0-0 home). Undefeated on the season, Jalen Hurts and the Eagles will look to defend their title, while Travis Kelce and Patrick Mahomes will be out for revenge. With a 4-3 record against Philadelphia since 2009, the Chiefs are tabbed as slim 1.5-point underdogs at home today.

Here are the FanDuel NFL betting odds for all 13 NFL games today! Let's take a deeper look at my best anytime touchdown scorer (ATS) bets, picks, and predictions for the Sunday, September 14 NFL matchups!

It's important to note, betting on a player to score a touchdown is a high-risk, high-reward option. I will emphasize responsible betting and bank roll management. My predictions and best bets can be found within FanDuel and DraftKings.

Are you in search of further NFL and sports betting promotions? We have compiled a list of the best sports betting offers here. 

NFL Week 2 Best Bets: Anytime Touchdown Scorer Predictions for Sunday, September 14

Jalen Hurts Anytime TD Odds: -120 (FanDuel)

2025-2026 NFL Stats

GP: 1  | CMP: 19 | Attempts: 23 | CMP: 82.6 % | Passing Yards: 152 | Passing TD: 0 | Pass Long: 51 | Rushing Yards: 62 | Rushing TD: 2

My first best bet for today, I placed one unit on Philadelphia Eagles star quarterback Jalen Hurts to score a touchdown against the Kansas City Chiefs.

Today's matchup features a rematch of Super Bowl LIX against the Chiefs, and we all remember Hurt's dominant performance in the Eagles 40-22 Super Bowl victory. Recording 72 rushing yards, Hurts did find the endzone for a touchdown.

I'm taking this momentum into today's game, and Hurts is coming off a two rushing touchdown performance against the Dallas Cowboys in week 1.

Why Jalen Hurts Can Score A Touchdown Against the Chiefs Today

While star receiver A.J. Browns' true health status in unknown, Hurts put up just 152 yards through the air, and Jahan Dotson led all Eagles' receivers with 59 yards.  The Eagles are notorious for the "tush push," behind a strong offensive line that includes Lane Johnson, Landon Dickerson, Cam Jurgens, Tyler Sheen, and Jordan Mailata.

Having lost to AFC West division rival Los Angeles Chargers in Brazil, 27-21, the Chiefs secondary and defense overall looked fragile. Quarterback Justin Herbert has emerged as a threat on the ground under Greg Roman, tallying 32 rushing yards in week one. While the Chargers didn't score a rushing towndown, they were 2-4 in the redzone.

Overall, Jalen Hurts is one of the most elite rushing quarterbacks, and heavily relied on his legs to secure a week 1 victory over the Cowboys. Now he faces a Steve Spagnuolo defense that gave up nine rushing touchdowns and just 70.4 rushing yards per game. Plus, they allowed a 53.97 percent conversion rate in the endzone last season.

Final NFL Anytime Touchdown Betting Prediction: Jalen Hurts ATS Odds: -120 (FanDuel)

In four career matchups against the Chiefs, Jalen Hurts has six rushing touchdowns, three of which came against the Chiefs in Super Bowl LVII. Although a small sample size, the Chiefs rank No. 17 in rush EPA (-0.070). While the defensive line is a bit weak on one side, the Chiefs do have Chris Jones and George Karlaftis.

• I'm taking Jalen Hurts to score a touchdown today. It's a corporate, yet popular bet, but a safe one. He's proven the Eagles are the best team to perform the Tush Push, and Hurts should find the endzone behind a strong offensive line.

James Conner Anytime TD Odds: -150 (DraftKings)

2025-2026 NFL Stats

GP: 1  | Carries: 12 | Rushing Yards: 39 | Avg Rushing: 3.3 | Rush TD: 5 | Rec TD: 1 | Rush Long: 12

My second best bet for today, I placed one unit on Arizona Cardinals running back James Connor to score a touchdown against Bryce Young and the Carolina Panthers.

This touchdown prop bet is a bit juiced a -150 odds, however, it still has great value. One of my favorite bets for the week, let me show you why it's a strong pick.

James Connor is the clear lead back, tallying 65 % of snaps in week 1. Although the Cardinals did deploy a two back committee, Trey Benson played just 33 percent of the snaps.  While both Connor and Benson split two carries each in the red zone, it was Connor who found the end zone with a receiving touchdown.

While it's unclear how offensive coordinator Drew Petzing will utilize both backs in the red zone, the Carolina Panthers gave up 200 rushing yards last week. With Travis Etienne Jr. recording 143 rushing yards for the Jacksonville Jaguars alone, it was Brian Thomas Jr. who found the endzone with a rushing touchdown.

The Panthers allow an NFL most 173 rushing yards per game, and last year they allowed the most rushing yards per game (148.2), along with 18 rushing touchdowns per game. That tied them for the most with the Saints, 49ers, and Bears.

Final NFL Anytime Touchdown Betting Prediction: James Connor ATS Odds: -150 (DraftKings)

I don't expect this to change much today given the Panthers rank No. 29 in rush EPA (.141). They have one of the weakest defense in the NFL, and a fairly delicate defensive line behind Pat Jones II and company. Even after signing Nic Scourton in free agency, Tershawn Wharton is set to miss 2-4 weeks with injury.

While quarterback Kyler Murray is capable of finding the endzone with his legs, this is a prime matchup for James Connor. Recording 39 rushing yards on 12 carries, Connor is very much a threat in the backfield.

• I'm taking James Connor to score a touchdown today. It's my best prediction gives he's crossed the plane in two of the last three matchups against the Panthers.

De'Von Achane Anytime TD Odds: -120 (DraftKings)

2025-2026 NFL Stats

GP: 1  | Carries: 7 | Rushing Yards: 55 | Avg Rushing: 7.9 | Rush TD: 0 | Rec TD: 1 | Rush Long: 26

My third best bet for Sunday, I placed one unit on Miami Dolphins De'Von Achane to record a touchdown against the New England Patriots.

In fact, when healthy, Achane is arguably one of the most elite backs in the league, possessing both speed and the ability to catch in the backfield. Last season, he rushed for 907 yards and six touchdowns. I the backfield alongside quarterback Tua Tagovailoa, Achane tallied 597 receiving yards and six touchdowns (12 total).

In the Dolphins 33-8 week 1 loss against Daniel Jones and the Indianapolis Colts, Achane managed to rush for 55 yards on seven caries. In addition, he tallied one receiving touchdown and 20 receiving yards in an abysmal offense. Demolished by the Colts, Tagovailoa tallied just 114 passing yards.

I'm expecting De'Von Achane to remain a critical part of the Dolphins' offense and lead running back for Mike McDaniel. Playing 73 percent of the snaps in week 1, Alec Ingold (27 % snaps) and Ollie Gordon II don't possess much of a threat.

Last week, Gordon II had the only rushing attempt for the Dolphins, and I am expecting a different outlook today. Divisional games are often competitive. Last week, the Patriots allowed Raiders rookie running back Ashton Jeanty to rush for 38 yards with one touchdown.

Final NFL Anytime Touchdown Betting Prediction: De'Von Achane ATS Odds: -120 (-120 DraftKings)

In conclusion, the Patriots allowed the eleventh most rushing touchdowns per game (15) last season. This may change under head coach Mike Vrabel given they rank No. 3 in rush EPA.

The Dolphins get a home matchup, where they will look to bounce back on both sides of the ball. With the departure of Raheem Mostert, Achane is a clear target of Tua's and top running back.

• I'm taking De'Von Achane to score a touchdown today. Additionally, he last recorded two against the Patriots in November 2024. In addition, he tallied seven touchdowns in the final eight games last year.