NFL Week 5 Anytime Touchdown Scorer Predictions: Best Bets for Sunday, October 5

NFL week 5 is here, and there are 12 games on the slate to bet on today!

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Sunday morning will feature an early morning matchup in London, featuring the Minnesota Vikings and the Cleveland Browns (1-3). Set to kick off at 9:30 am ET, the game will be broadcast on the NFL Network.

Key NFL Matchups: Week 5

Baker Mayfield and the Tampa Bay Buccaneers (3-1, 2-0) will face Sam Darnold and the Seattle Seahawks (3-1,1-1 home) on the road.  A 3.5-point spread favorite, the Seahawks will get another matchup at home. Riding a three-game win streak, both Tampa and Seattle are among the top NFC teams through week 5. The Seahawks have the thirteenth-best odds to win the Super Bowl (+3300), while the Buccaneers have the same odds to raise the Lombardi Trophy!

Up next, Jalen Hurts and the Philadelphia Eagles (4-0, 2-0 home) will host Bo Nix and the Denver Broncos (2-2, 0-2 away). Undefeated, the Eagles are a 4.5-point spread favorite on Sunday. Featuring top quarterbacks in Hurts and Nix, can the Broncos hand Philadelphia its first loss this season? The Eagles are 3-1 against the Broncos since 2009.

Sunday Night Football: New England Patriots vs Buffalo Bills

The weekly Sunday night matchup is an AFC divisional matchup between the New England Patriots (2-2, 1-0 away) and the Buffalo Bills (4-0, 3-0). Featuring quarterbacks Drake Maye and Josh Allen, the Bills are massive 8.5-point spread favorites at home in Orchard Park. The Bills have gone 7-3 against the Patriots since 2020, and the books are largely favoring them, who are undefeated on the season.

Are you in search of further NFL and sports betting promotions? We have compiled a list of the best sports betting offers here. 

NFL Week 5 Best Bets: Anytime Touchdown Scorer Predictions for Sunday, October 5

Cam Skattebo Anytime TD Odds: -130 (FanDuel)

2025-2026 NFL Stats

GP: 4  | Carries: 48 | Rushing Yards: 181 | Avg Rushing: 3.8 | Rush TD: 2 | Rec TD: 0 | Rush Long: 24

My first best bet for today, I placed one unit on New York Giants running back Cam Skattebo to score a touchdown Sunday against the New Orleans Saints.

Tyone Tracy Jr. is set to miss a third consecutive week with a shoulder injury. That means Skattebo should once again be the lead back.

In his first NFL season, Skattebo has impressed, tallying 60 and 79 rushing yards over the last two weeks against the Chiefs and Chargers. Not to mention, he's a threat receiving in the backfield, and has rushed for two touchdowns in four weeks.

Why Cam Skattebo Can Score a Touchdown Sunday vs The Saints

I'm confident given Skattebo played a career-high 75 percent of the snaps in week 4, and leads the Giants with 32 rushing yards on 14 attempts inside the 20. In the red zone this season, he's rushed 93.3 percent of the time. Trailing is Devin Singletary with one rushing attempt.

Skattebo and the Giants face a Saints team who are looking for their first win of the season. Although on the road, they give up the fifth most rushing touchdowns to running backs this season.

Since September 7, the Saints' defense has given up two touchdowns to Kenneth Walker Jr. (Seahawks) and one each to James Cook (Bills), Christian McCaffrey (49ers), and James Connor (Cardinals).

Overall, the Saints' defense has been atrocious, allowing the third most points per game (30.3) behind the Ravens and Cowboys. Following the Derek Carr era, they've been one of the least efficient teams on the offensive end.

Final NFL Anytime Touchdown Betting Prediction: Cam Skattebo ATS Odds: (-130 FanDuel)

Without top receiver Malik Nabers (ACL), I'm expecting the Giants to pound the football on the ground today. After all, the Saints allow nearly a 77 percent conversion rate in the red zone, and they rank No. 16 in rush EPA.

• I'm taking Cam Skattebo to score a touchdown against the New Orleans Saints on Sunday. 

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Emari Demercado Anytime TD Odds: +300 (FanDuel)

2025-2026 NFL Stats

GP: 4  | Carries: 4 | Rushing Yards: 8 | Avg Rushing: 2.0 | Rush TD: 0| Rec TD: 1 | Rush Long: 8

My second-best bet for Sunday, I placed one unit on Arizona Cardinals running back Emari Demercado to score a touchdown against the Tennessee Titans.

It was unfortunate that James Connor was placed on the injured reserve with an Achilles injury. Now, Trey Benson is a member of the IR with a knee injury. That leaves Emari Demercado and Michael Carter as the remaining backs for the Cardinals.

Rumors are swirling around that Demercado will be the third-down back while Michael Carter will take over the duties. It's hard to envision this, given that Demercado played 39 percent of snaps in week 4 compared to Carter's six percent. All things considered, I expect him to be the starting running back on Sunday.

It will be the first whole week without Benson or Connor, and Demercado already has one receiving touchdown on the season.

Todau, Demercado, and the Cardinals get a prime matchup against the Titans, who rank No. 30 in rush EPA, and have allowed an NFL-high six rushing touchdowns on the season.

Final NFL Anytime Touchdown Betting Prediction: Emari Demercado ATS Odds: (+300 FanDuel)

Let's face it, Tennessee allowed three touchdowns to Colts running back Jonathan Taylor. While Demercado has just eight rushing yards on the season, sure, it's a gamble. However, I love the matchup and value at +300 odds.

• I'm taking Emari Demercado to score a touchdown Sunday vs the Titans. Quarterback Cam Ward has openly criticized the Titans, and they have been less than stellar on both sides of the ball. Plus, opponents are scoring just over 58 percent in the red zone against Tennessee.

Garrett Wilson Anytime TD Odds: +135 (FanDuel)

2025-2026 NFL Stats

GP: 4  | REC: 27 | Targets: 38 | Receiving Yards: 311 | Receiving TD: 3 | Receiving Long: 33 | First Down: 14

My last best bet for Sunday, I placed one unit on New York Jets star wideout Garrett Wilson to score a touchdown against the Dallas Cowboys.

Quarterback Justin Field is back, and Wilson is the clear No. 1 receiver on the Jets. Leading the team by a mile in receptions (27), targets (38), receiving yards (311), and receiving touchdowns (3), he's Fields' top receiver.

Recording 80+ receiving yards over the last two weeks, and three of the four games this season, Wilson now has a touchdown in two consecutive games against the Buccaneers and Dolphins.

Ahead of Tyler Johnson, Arian Smith, Josh Reynolds, and Allen Lazard in the depth chart, Wilson played 100 percent of snaps in week 1 and week 3. In week 4, he played 98 percent of the snaps!

Often lining up in the wide vs the slot, Wilson has an excellent matchup against a weak Cowboys secondary. He has the advantage against either Kaiir Elam or DaRon Bland, and faced a Dallas defense that allows the most touchdowns to receivers in 2025.

Final NFL Anytime Touchdown Betting Prediction: Garrett Wilson ATS Odds: (+135 FanDuel)

He should feast against Dallas, which allowed multiple touchdowns to receivers this season. Romeo Doubs (Packers) scored three alone last week, while Malik Naber (Giants) scored two touchdowns in Week 2. Given they've allowed six receiving touchdowns to receivers in three weeks, I genuinely don't trust this defense. WR1 or WR2, it doesn't matter—teams are feasting against Dallas.

• I'm taking Garrett Wilson to score a touchdown Sunday against the Cowboys. Dallas allows opponents to score 64.7 percent of the time in the red zone, ranking them No. 31 in success rate. Wilson is a premier receiver in the league, and this is one of his best matchups of the season. Look for the touchdowns to keep rolling today!