NFL Prop Bets Week 15: Bills vs Lions NFL Picks and Predictions (Sunday, December 15)

The Buffalo Bills and Detroit Lions are both on the hunt for the No. 1 seed in their respective conferences, and that'll make a game on Sunday between two of the best teams in football that much more entertaining.

(Photo by Kevin Sabitus/Getty Images)

Sunday should present a great chance for the Lions to remain dominant through the air, but in a twist this could be a rare spot where their run defense finally caves with injuries mounting.

Without further ado, let's get into the best NFL player prop bets to make for Bills vs. Lions in Week 15.

BEST NFL PROP BET: Jared Goff 2+ Passing Touchdowns

Best Odds: -155 at DraftKings

It's not exactly the cheapest bet on the board, but I do think there's plenty to like about Jared Goff in this one -- and there's little value to be found in his yardage total.

• The Bills have improved by leaps and bounds defensively, headlined by a near-top 10 DVOA against the pass, but in the last five weeks they're down in the bottom five of teams in EPA allowed per dropback.

Buffalo's secondary stands as a sizable liability here given the recent form, especially with a pair of safeties in jeopardy of missing this game, and that should open things up for Goff to once again find some success through the air.

• The Bills held Brock Purdy in check a couple of weeks ago, but that was the only time in their last five games they've held an opposing passer under two touchdowns.

Buffalo ranks just 16th in red zone defense and has allowed more than two touchdowns per game, and with Goff throwing for multiple scores in four of his last five I think this is a bet we have to take.

BEST NFL PROP BET: Jahmyr Gibbs Over 2.5 Receptions

Best Odds: -138 at FanDuel

Next, we'll look to hunt down the man who should be the biggest beneficiary of what looks like a soft matchup for this high-octane Lions passing game. Ironically, it's a running back.

• I'm admittedly bullish on both Lions running backs in the passing game, given the Bills have allowed 7.1 targets per game to the position -- the most in the NFL.

Gibbs, who plays slightly more of the snaps than David Montgomery, will be my choice. He's received a whopping 10 targets over the past two weeks as Dan Campbell's team looks to maximize the number of touches heading to arguably his best play-maker, and this spot should feature more of the same.

Buffalo's linebacking corps has failed to contain shifty backs like Gibbs, and regardless of the matchup it's been clear that Detroit has looked to use pre-snap motion to place Gibbs in space where he can look for an explosive play on a screen pass.

The youngster has hauled in three passes in just about half of his games, and the trends would point to yet another busy day for him.

BEST NFL PROP BET: James Cook Over 48.5 Rushing Yards

Best Odds: -113 at Caesars

Heading to the other side of the ball, there are a myriad of ways in which we've made money off an explosive Buffalo Bills offense this year. While it would seem to be a tough call to whittle this down to one man, I think James Cook is the player who's simply not receiving enough love from oddsmakers this week.

• The third-year back has remained steady this year with a solid 4.6 yards per carry, but he's been anything but consistent with two straight 70-yard outings following two games where he failed to hit 40.

Well, that's confused oddsmakers enough to set his total at a speculative 48.5 yards -- and I'll be the first in line to take the discount.

Detroit may be a menacing defense against the run, but it's trailed off ever so slightly in ranking just ninth in EPA allowed per rush in the last five weeks -- and with a laundry list of linebackers and down lineman on the shelf things should continue to be a bit trickier for this group than it's used to.

Enter Cook, who's gone well over this number in back-to-back games and will head a rushing attack which has produced 638 total yards in the last five weeks, and I think we've got another winner.

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