MLB Prop Odds Today: Best Picks for Wednesday August 6, 2025

Ohtani on the mound to face the Cardinals in Los Angeles

Here are the National League MVP Award odds for Shohei Ohtani from three of the most popular sportsbooks:

• FanDuel: -400
• BetMGM: -425
• DraftKings: -450

The LA Dodger superstar has an excellent chance to add a fourth MVP award in the last five seasons. The Japanese slugger has turned back into slugger/ace for the Dodgers. In seven starting assignments, Ohtani has a 2.40 ERA (albeit in only 15 innings).

(Photo by Stephen Maturen/Getty Images)

With his 58-homer pace and rejuvenated pitching arsenal, Ohtani is poised to be a two-way threat in October's playoff baseball.

Which means the Dodgers have to be favorites to win a second straight World Series titles

Oddsmakers at FanDuel have the Dodgers at +230 to win the Fall Classic. You can get better odds at DraftKings, which prices LA at +300.

Tonight, Ohtani makes his first start against the Cardinals, taking the mound at Chavez Ravine.

The Cardinals have managed no more than 3 runs in 8 of its last 11 games

The lineup is trying to limp along into the warm, late summer. The Redbirds are humming along at the speed limit, a .500 team that's more mediocre than marvelous.

Ohtani odds for strikeouts tonight are advantageous. That's why this is our best MLB player prop bet for Wednesday, August 6:

Best Bet: Shohei Ohtani 5+ strikeouts vs Cardinals at +110 from DraftKings sportsbook.

If you are interested in a Ohtani parlay, here's a Same Game Parlay:

• Shohei Ohtani 4+ Strikeouts as a Pitcher
• Shohei Ohtani to Hit a Home Run
• Odds from FanDuel: +233

That means a winning $100 bet will gain you $233 if Shohei goes deep AND strikes out 4 Cardinals' batters tonight.

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Best Game Props: Astros at Marlins

Are you sick of it yet? This is about the 10th straight season that I've chosen the Astros to win the pennant. I've been correct many times, but admit it: you thought 2025 would signal the end of the Houston dynasty.

Not so fast, baseball fans.

The Astros have a firm grip on the American League West (again)

The Astros have the deepest pitching staff in the AL (again). The Astros have the smartest coaching staff, analytics team, and front office in the sport (again).

Which is why I still like the Big Orange Winning Crew to capture another division title and go far into the MLB playoffs.

On Wednesday, the Astros are entertaining the Marlins, a team making an unexpected push for a playoff spot. The game props for this contest are appetizing.

HOU vs MIA: First 5 Innings Result, Astros +128

Wager $50 on Houston to win the first 5 full innings, and you win $64 outright if the Astros have the lead.

I like Spencer Arrighetti to bounce back from recent struggles on the hill for Houston

In his last three starts, the young righty has increased the spin rate on his two best pitche, the four-seam fastball. Opposing batters are hitting a sickly .053 against that pitch.

If Arrighettin can get that pitch into the zone, the Marlins will struggle to square him up.

1+ Extra Base Hit in the First Inning, HOU at MIA: +220

If at least one Astro or Marlin batter hits an extra-base hit (double, triple, home run) in the first frame, your $100 wager would be worth $220 in winnings.

Home Run Props: Mariners vs White Sox

The Mariners have one of the most feared lineups in MLB following a flurry of deals at the trade deadline. Last night Josh Naylor hit his second home run in a Mariners' uniform.

Big bopper Eugenio "Geno" Suárez has yet to hit a four-bagger in his second stint with Seattle

The right-handed slugger is on pace for more than 50 jacks, which would break his prior record of 49.

Best HR Props for Tonight's MLB Games

Facing the pitiful pitching staff of the White Sox tonight, the Mariners seem a good choice for a few home runs.

Here are the best odds for HR's by SEA batters tonight, in order of our preference for a vs CHW wager:

• Suárez +255
• J.P Crawford +900
• Cal Raleigh +200

If you wager $100 on Cal Raleigh to go deep tonight and the switch-hitting catcher does, you win $200, plus your stake goes back into your account. That according to FanDuel Sportsbook.