NFL Predictions for Monday (September 23): Jaguars vs Bills Betting Odds and Best Bets

We are now 2 weeks in the books and while many believed the Bills would take a step back after losing some key players on offense, they are continuing their momentum from last season to a 2-0 start in 2024.

The Jaguars on the other hand are limping into their Week 3 road tilt losing both games to start and are looking to rebound on the road in Buffalo on Monday night.

This game has the makings of being a shootout between these two high-flying offenses, so let's take a look at our Jaguars-Bills prediction and pick.

(Photo by Bryan M. Bennett/Getty Images)

Why The Jacksonville Jaguars Will Cover The Spread

The Jacksonville Jaguars are having a rough start to their 2024 campaign as they have dropped both of their first 2 games of the season.

However, both games came down to the wire and each loss were by less than a touchdown giving them a glimpse of hope coming into this matchup with the Buffalo Bills.

• The Jaguars' defense has given up just 18 ppg through 2 weeks which is tied for 8th in the NFL and allowed just 103 yards per game on the ground good for 11th in the league.
• While the Jaguars offense has been a dud to start the season, they still have talent across the field with Trevor Lawrence, Travis Etienne, Gabe Davis, and Brian Thomas Jr. that it's only a matter of time before they break out

The Jacksonville Jaguars Are +4.5 Point Spread Underdogs Monday

The Jacksonville Jaguars are looking to rebound from back-to-back losses to start the season. They have been stagnant on offense however, they will need a big game from Trevor Lawrence and company if they want to get the big primetime victory on the road against the Buffalo Bills.

• Trevor Lawrence has had success against the Buffalo Bills in his career with a passer rating of 88.9, 433 passing yards, and 1 touchdown.
• Don't forget about the Jaguars' lead running back Travis Etienne who had 26 carries for 136 yards and 2 touchdowns in his only game against the Bills.

The Jaguars have the talent to make a deep run this season but they just need to put it all together. If Lawrence and company can play as they have in the past against the Bills, the Jaguars have the chance to finally get their first win of the season in hostile territory.

Why The Buffalo Bills Will Cover The Spread

The Buffalo Bills weren't the same team coming into the start of the season which had them being the talk of the offseason. Many analysts believed that Josh Allen and this Buffalo Bills team would take a step back but that couldn't be further from the truth.

They got out to a roaring 2-0 start and this new-look Bills offense has looked better than years past even with the departures of Stefon Diggs and Gabe Davis.

While Josh Allen runs this offense, this is the most balanced Buffalo Bills attack we have seen yet.

• James Cook went off against divisional rivals Miami Dolphins with 95 all-purpose yards and 3 touchdowns.
• Josh Allen through 2 weeks has 371  passing yards, 3 passing touchdowns, and a passer rating of 124.2.

Josh Allen has played well against the Jaguars in his career, with 783 passing yards, 3 touchdowns, and 3 interceptions, and he has a passer rating of 82.4 through 3 career games. Now, with less of this offense being solely on his shoulders he will be more efficient than in years past.

Expect this Bills offense to come out of the gate hot like they have through the first two weeks where they have averaged 32.5 ppg which is 3rd in the NFL.

While this Jaguars team has held both Miami and Cleveland in check through the first two weeks, they have given up a ton of yards, resulting in points against Allen and company this time.

MNF WEEK 3 BETS: JACKSONVILLE JAGUARS vs BUFFALO BILLS FANDUEL ODDS FOR SEPTEMEBER 23RD

MONEYLINE

• JACKSONVILLE JAGUARS: +198
• BUFFALO BILLS: -240

SPREAD

• JACKSONVILLE JAGUARS: +4.5 (-105)
• BUFFALO BILLS: -4.5 (-115)

OVER/UNDER (TOTAL)

• OVER: 45.5 (-115)
• UNDER: 45.5 (-105)

BEST ODDS FOR JACKSONVILLE JAGUARS vs BUFFALO BILLS

• The Jacksonville Jaguars head to Buffalo searching for their first win of the season as the betting underdogs. BetMGM Sportsbook currently offers the Jaguars with the best odds at +5.5 (-102)
• Josh Allen and the Buffalo Bills look to remain unbeaten when they play host to the Jacksonville Jaguars as the favorites in this matchup. FanDuel Sportsbook currently offers bettors with the best odds at -4.5 (-115)
• DraftKings currently offers the best odds for the game total, which has a total of 45.5 (-110) for the over, and (-110) for the under

JACKSONVILLE JAGUARS vs BUFFALO BILLS INJURY REPORT

JACKSONVILLE JAGUARS INJURY REPORT INJURY REPORT

1. C. ROBINSON - KNEE
2. E. ENGRAM - HAMSTRING
3. D. SAVAGE - QUADRICEP
4. T. BIGSBY - SHOULDER

BUFFALO BILLS INJURY REPORT INJURY REPORT

1. D. SMOOT - TOE
2. M. TRUBISKY - KNEE
3. J. ALLEN - LEFT HAND
4. T. JOHNSON - FOREARM
5. T. BERNARD - PECTORAL
6. Q. MORRIS - SHOULDER
7. T. JOHNSON - KNEE
8. C. TOOHILL - KNEE
9. J. SOLOMON - OBLIQUE

NFL FINAL JAGUARS-BILLS PICK & PREDICTION

One of two games on Monday Night Football kicks off with the Jaguars and Bills which should be a high-scoring affair between these two powerhouse offenses.

Ultimately, Josh Allen and this new-look Bills offense is going to be too much for this Jaguars defense to contain as they come out there putting the Jaguars on their heels from the get-go and as they pour it on Trevor Lawrence will not be able to catch up as the Bills remain unbeaten while covering the spread at home.

FINAL JAGUARS-BILLS PICK & PREDICTION: BUFFALO BILLS -4.5 (-115)