NFL Best Bets for Tonight's TNF (December 12): Rams vs 49ers Betting Odds and Best Bets

NFL week 15 is here, and we have a NFC West showdown between the Los Angeles Rams (7-6, 3-3 away) and the San Francisco 49ers (6-7, 4-3 home). Second in the division, the Rams trail the Seahawks by just one game and remain in the hunt for the playoffs. With an 11 percent chance to sneak into the postseason, tonight is a must-win for the 49ers. Either way, get your popcorn out. This should be a movie tonight!

 (Photo by Dustin Satloff/Getty Images)

There's no team that's more confident than the Rams right now. With star receivers Cooper Kupp and Puka Nacua nursed back to full health, they're just as dominant as anyone on the offensive end. As bettors, we saw that with a week 14 statement 44-42 victory over the Buffalo Bills. With a stellar performance by Stafford, the Rams excelled in maintaining possession and third down conversions. Totaling 457 yards of offense, 162 of them went to Nacua. 3-1 in their last four matchups, they get a tough test tonight.

On the flip side, Kyle Shanahan and the 49ers are fighting for their lives. Following the devastating season ending injury news to running back Christian McCaffrey, it's up to Isaac Guerendo and Patrick Taylor Jr. to step up in the backfield. While the 49ers steamrolled the Bears 38-13 in week 14, they've dropped three of their last four games. With injuries piling up, the 49ers will feel the absence of McCaffrey, Trent Williams, Brandon Aiyuk, and Jon Feliciano, just to name a few.

With the Rams 2-0 vs the 49ers in their last head-to-head matchups, the 49ers are 7-3 vs the Rams over the last ten meetings. Will there be an upset tonight, or will San Francisco continue their hot streak at home?

Odds Are Current As Of December 12 AT 8 A.M. ET

If you're looking to tail some TNF player prop bets, you've come to the right place! +3 point underdogs, the Rams will look for their third straight victory vs the 49ers on the road. With an NFL betting record of 29-19, I am up 3 units in December. Looking to keep the units flowing, I've provided my best bets, which include a mixture of various player prop wagers tonight.

With kick-off slated for 8:15 p.m. ET, the Thursday TNF matchup will air on Prime Video. Located at Levi's Stadium, I'm anticipating a close matchup between the two division rivals.

With the option to parlay these picks, I've chosen to play them as straight plays, all with bank roll management in mind.

First, let's analyze the current DraftKings odds for the December 12 week 15 TNF matchup between the Rams and 49ers.

Are you in search of further NFL and sports betting promotions? We have compiled a list of the best sports betting offers here. 

NFL WEEK 15 BETS: Los Angeles Rams vs San Francisco 49ers DraftKings Betting Odds For December 12

MONEY LINE

• LOS ANGELES RAMS: +120
• SAN FRANCISCO 49ERS: -142

SPREAD

• LOS ANGELES RAMS: +3 (-122)
• SAN FRANCISCO 49ERS: -3 (+102)

OVER/UNDER (TOTAL)

• OVER: 48.5 (-112)
• UNDER: 48.5 (-108)

Last Five H2H Matchups: Los Angeles Rams vs San Francisco 49ers

• September 22, 2024: Rams 27, 49ers 24 (LA +6.5, over 44.5)
• January 7, 2024: Rams 21, 49ers 20 (LA +5.5, over 40.5)
• September 17, 2023: 49ers 30, Rams 23 ( LA +7.5, over 45)
• October 30, 2022: 49ers 31, Rams 14 (SF -1, over 42.5)
• October 3, 2022: 49ers 24, Rams 9 (SF-1, under 42)

Los Angeles Rams vs San Francisco 49ers Injury Report

RAMS

1. Jordan Whittington, WR: Questionable
2. Davis Allen, TE: Questionable
3. Alaric Jackson, OT: Questionable
4. Cobie Durant, CB: OUT
5. KT Leveston, G: IR

49ERS

1. Nick Bosa, DE: Questionable
2. Isaac Guerendo, RB: Questionable
3. Trent Williams, OT: OUT
4. Malik Mustapha, S: OUT
5. Dre Greenlaw, LB: OUT

NFL Predictions for Thursday, December 12 Week 15: Rams vs 49ers

NFL Player Prop Best Bets Tonight: George Kittle

2024-2025 NFL Season Stats

GP: 11  | Receptions: 56 | Targets: 67 | Receiving Yards: 800 | Avg: 14.3 | Rec TD: 8 | Rush TD: 0 | Long Rec: 43 | First Down: 37

• Over 23.5 Longest Reception (-125 DraftKings)

My first best bet for tonight, I placed one unit on 49ers tight end George Kittle to record over a 23.5 yard longest reception vs the Rams. One of the most elite tight ends in the game, Kittle is quickly becoming a favorite target of Brock Purdy's. With frustration piling up for Deebo Samuel Sr, he's taken a back seat with the emergence of both Kittle and Jauan Jennings.

On pace for another 1000+ receiving season, Kittle has stepped up in more than one way after the 49ers lost receiver Brandon Aiyuk with an ACL tear. The leader in receiving yards (800), Kittle is the clear top second option for Purdy next to Jennings. Averaging 72.7 yards per game, the tight end has put up some monster performances.

• One includes a season-high 151 yards and a longest reception of 33 yards last week vs the Bears.

Why George Kittle Can Be Successful vs An Average Rams Defense

If you're betting on the NFL, there's one aspect to know about Kittle. He's familiar with the Rams, since they are in the same division. Given Los Angeles is allowing the 13th most yards to tight ends, Kittle should have a field day tonight. Not to mention, tight ends average over 10 yards per carry vs the Rams.

Often Kittle has lined up on the right side more times than not. Averaging over 39.8 percent of plays in the right tight, Kittle should feast against a weak sided defensive line and linebacker core. Aside from Jared Verse, the Rams can very much be exploited in this positions.

As the weeks have gone on, we've seen various tight ends have success down the field vs LA. Juwan Johnson, of the Saints, tallied a 21 longest reception in week 13. In week 10, Dolphins tight end Jonnu Smith erupted for a 33 yard longest reception. In addition,

• Josh Oliver (25)
• Brock Bowers (25)
• Tucker Kraft (66)
• Cole Kmet (22)
• Eric Saubert (20)
• Trey McBride (21)
• Sam LaPorta (18)

Are all tight ends that have completed long receptions vs the Rams. In fact, there's been several weeks tight ends have been atop of the leading receiving board against LA. Given the Rams allow the third most longest receptions to tight ends, and 7th most yards over all, this is a strong best bet for tonight.

Brock Purdy Has Extraordinary Chemistry With George Kittle

Now, let's look at Kittle's production, specifically over the last seven weeks or so. Whether Deebo Samuel Jr. is a factor or not, a quarterbacks best friend is a tight end. And with his long and strong frame, Purdy should have no problem connecting with Kittle tonight. 7th in the NFL with 9 40+ yard passes, Purdy is fourth in 20+ yard receptions with 45. With Kittle leading the league with 15 20+ yard receptions, this is a no brainer.

Aside from an outlier matchup vs the Bills, Purdy has targeted Kittle over 5 times per game since Aiyuk went down with an injury. Averaging 85 yards per game over the last five weeks, there's insane chemistry between Purdy and Kittle. I'll add in that span, the tight end is averaging a longest reception of 29.4 yards.

Final TNF NFL betting prediction: George Kittle Over 23.5 Longest Reception (-125 DraftKings)

Averaging a solid 14.3 yards per reception, Kittle ranks atop with a season high 43 long haul. Given the Rams have more strength at safety than corners and linebackers, that's why I love this player prop the most. Averaging 47.4 air yards per game and 16.5 % of the team air yards, it's safe to safe I'm not fading this play. Unlike no other, Kittle is in a league of his own. With 6.7 yards after catch, he's soared over this line in four of the last five weeks.

In fact, Kittle is averaging a longest reception of over 34 yards over that span. Able to hit the over in 8/11 regular season games, the average longest reception hasn't nearly been close to this prop number.

• Averaging a longest reception of 27 yards, I'm taking George Kittle to record over 23.5 yards for his longest vs a subpar Rams defense tonight. 

NFL Player Prop Best Bets Tonight: Jauan Jennings

2024-2025 NFL Season Stats

GP: 11  | Receptions: 57 | Targets: 78 | Receiving Yards: 774 | Avg: 13.6 | Rec TD: 6 | Rush TD: 0 | Long Rec: 45 | First Down: 38

• Over 69.5 Receiving Yards (-115 DraftKings)

My second best bet for Thursday, I placed one unit on 49ers receiver Jauan Jennings to record over 69.5 receiving yards vs the Rams. I sure grabbed this line early on DraftKings, and only expect it to increase today.

Having a career-year, Jennings has stepped up nicely in the place of Aiyuk. With Samuel Sr. taking a back seat to Jennings, there's no question he's one of Brock Purdy's trusted receivers. Leading all receivers with targets and receptions, has Jennings solidified himself as the true WR1?

We already know Jennings monstrous career game coincidently took place vs the Rams in week three. Tallying 175 yards on 11 receptions, Jennings truly went off, and that's when Aiyuk was still in the lineup. While the 49ers were without both Kittle and Samuel, I don't expect Jennings to produce this high volume again.

Jauan Jennings Torched The Rams Early In The Season

In an overall dominant performance, the receiver torched the Rams defense, in the end zone, slot, and wide. With three touchdowns on the game, can we forget Jennings vertical grab over Quentin Lake? I know one aspect, Johnson was able to cook up the Rams anywhere on the field. And multiple catches came between several defenders.

Averaging 90 yards per game through 11 games, we've really seen Jennings productivity increase over the last five weeks. Recording over 69.5 receiving yards in three of the last five games, Jennings has a chance to crush this again tonight.

• Pulling 90+ receiving yards vs the Buccaneers, Seahawks, and Bears, Jennings is averaging over 11 targets alone over that span.

Although a bit inconsistent earlier in the season, it seems Jennings has found his groove. Regardless of Samuels frustration with his role, I'm still banking on Burdy to connect with Jennings quite a bit tonight. With 25 receptions over the last five games, he's the clear no. 1 option next to Kittle. I truly mean this, given Jennings led all receivers with 7 receptions and two touchdowns vs Chicago.

Final TNF NFL betting prediction: Jauan Jennings Over 69.5 Receiving Yards (-115 DraftKings)

10th in EPA/play, Purdy and company are one of the best in dropback EPA. Given the Rams rank 29th in Dropback EPA, Purdy should have more than enough time in the pocket. Losing Trent Williams in the offensive line will be hard to replace,  "Mr. Irrelevant" last torched the Rams for 292 passing yards in week 3.

Aside from the Purdy to Jennings connection, the receiver gets a solid matchup against the Rams, who are middle of the road vs receivers. Allowing over 150 yards per game to wideouts, LA allows the second most yards per catch to wideouts with 14.86 yards.

With Jared Verse looming large on the end, the Rams don't have a strong secondary, which we saw last week vs the Bills. Averaging 68.3 air yards per game, Jennings is averaging 21.5 % of the 49ers targets. With a low drop rate, Jennings outperformed Samuel last week despite losing the snap count.

This number is slightly elevated, but I'm rocking with it anyway. Eclipsing 90+ yards two of the last five head-to-head matchups vs the Rams, he faces LA, who recently allowed Khalil Shakir (106) and A.J Brown (109 yards) to ball out.

• One of my best predictions of tonight, I'll take Jauan Jennings to tally over 69.5 receiving yards. 

NFL Player Prop Best Bets Tonight: Kyren Williams

2024-2025 NFL Season Stats

GP: 13  | Carries: 251 | Rushing Yards: 1,013 | Avg: 4.0| Rush TD: 4 | Rush TD: 12 | Long Rush: 30 | First Down: 70| Rec Yards: 155 | Rec TD: 2

• Over 73.5 Rushing Yards (-115 DraftKings)

My last best bet for TNF, I placed one unit on Rams running back Kyren Williams to record over 73.4 rushing yards vs the 49ers. Sure, the 49ers allow the 7th least yards on the ground with 138.9 yards per game. However, they've lost several of their defensive lineman, linebackers, and safeties to injury. If Nick Bosa is unable to suit up tonight, I love this player prop bet even more.

With injuries piling up for the 49ers, they've been one of the least efficient teams against the run as of late. Allowing the third most rushing yards in the NFL over the last three weeks (152.3), we saw James Cook, Ray Davis, Ty Johnson for the Bills combine for 198. One week prior, Packers back Josh Jacobs exploded for 106 yards, and Emmanuel Wilson for 41.

Kyren Williams Cooked The 49ers For 89 Yards In Week 3

As weak as the 49ers defensive line is, I'll take this prop all day. One of my strongest best bets for Thursday, the Rams by far call passing plays more than anything. With LaFleur calling run plays 41 % of the time, Williams should get his share tonight.

It's clear as day Kyren Williams is the no.1 back for the Rams, even if rookie Blake Corum get's some touches. Out snapping Corum 83 % to 17 % last week, I'm confident Williams is "the guy." A touchdown machine with 12 on the year, he has been as efficient as years prior. However, Williams has stepped up his productivity, especially over the last four weeks. Given his yards per carry has been an issue (4.o), it's improved over the span.

In one gutsy 27-24 victory over the Rams in week three, we saw Williams get his typical 89 yards on 24 attempts. Although 3.7 yards per carry wasn't the most efficient, it got the job done. I expect Williams to easily hit this total again tonight.

Final TNF NFL betting prediction: Kyren Willaims Over 73.5 Rushing Yards (-115 DraftKings)

We know Williams will receive a hefty amount of carries. Coming off a season high 29 carries and 87 yards vs the Bills, I will admit that's terrible production. However, Averaging 5 yards per carry over the last four weeks, the back is pounding an average of 87+ yards on the ground. I will say, I was relieved when Williams exploded for 104 yards for 6.9 yards per carry vs the Saints.

Eclipsing over 73.4 in four straight games, Williams has hit this rushing total in 9 of 12 games this year. Third in NFL touches among running backs with 279, there's no doubt in my mind he'll get the carries. It's more or less the yards per carry and efficiency vs the 49ers.

Since the 49ers are 28th in rush EPA, I'll take Kyren Williams to record over 73.5 rushing yards on the ground.