Best Same Game Parlay Tonight: SGP Picks for 49ers vs Bills on Sunday Night Football (Dec 1)

A great game on paper when the schedule was released over the off-season has a different feel to it after 11 games, with the mighty San Francisco 49ers entering a big matchup with the Buffalo Bills on primetime as six-point underdogs.

(Photo by Cooper Neill/Getty Images)

With plenty left to play for in a weak division and a potential way into this matchup on the ground, might there be some spots to play player props with the 49ers?

Let's highlight a few players who should shine under the lights as we build a same-game parlay for 49ers vs Bills on Sunday Night Football this week.

Best Same Game Parlay for 49ers vs Bills on Sunday Night Football

Odds: +525 at DraftKings

• Christian McCaffrey 100+ Rushing + Receiving Yards
• Josh Allen Over 32.5 Rushing Yards
• Deebo Samuel 50+ Rushing + Receiving Yards

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Christian McCaffrey 100+ Rushing + Receiving Yards

I alluded to it earlier, but if there's one way to beat the Bills it's certainly on the ground.

• Buffalo's rank against the run has come in several spots blow where it sits against the pass, and it stumbled into the bye with at least 4.6 yards allowed per carry over the last three games.

Enter Christian McCaffrey, who's been getting his legs underneath him after returning from injury in Week 9 but has had to combat some great rushing defenses. While Buffalo's isn't all that bad, the linebacking group here is somewhat weak and if he can just get to the second level I believe this is the game where the star back will finally break out.

• I'm a fan of skipping over McCaffrey's rushing total here and opting for his rushing and receiving yards, not only because he's done much better work as a pass-catcher since his return but given the matchup at hand.

The Bills have done a bang-up job at containing the tight end position, which should take away one of Brock Purdy's options here, but they rank just 17th in DVOA allowed through the air to opposing running backs.

With that, I think the 49ers -- ranked inside the top 10 in rushing rate this season -- will look to lean heavily upon McCaffrey to get the offense going under the lights.

Josh Allen Over 32.5 Rushing Yards

I realize I'm selecting some heavily-bet players by the public, but the matchup here is hard one to crack given both defenses have been rather strong this season.

• I landed on Josh Allen's rushing total, attempting to read into San Francisco's schedule to gain an edge.

While San Francisco hasn't allowed a plethora of big rushing days to opposing quarterbacks, it's faced just four signalcallers all year that can move the ball with their feet. Baker Mayfield was the only on who was reluctant to run, while Kyler Murray rushed seven times for 83 yads, Patrick Mahomes racked up 39 yads on five carries and Geno Smith managed 29 on four rushes.

• When you put it all together, the 49ers are allowing over six yards per carry to quarterbacks, and judging by his most recent games it's safe to say Allen is going to be inclined to run the ball here.

The 49ers' pass rush remains relatively strong, which should flush Allen from the pocket like we saw in the last two weeks. He's rushed a total of 20 times in his last two games for 105 yards and should lean on his legs plenty here to eclipse this total by some margin.

Deebo Samuel 50+ Rushing + Receiving Yards

I'd normally roll my eyes at backing Deebo Samuel against a stingy defense, particularly amidst a tough season, but I do think this matchup is calling his name.

• Buffalo's ranked near the bottom of the league in DVOA allowed to the WR1 and WR2 positions, doing an excellent job against slot receivers and tight ends, and as we expect Samuel to line up outside plenty he should be a key target for Purdy as he looks to find the soft spots in this defense.

I'm constantly trying to find ways to attack this Bills secondary, which has been by far the weakest part of this team, and while Samuel does generally operate just a few yards away from the line of scrimmage the potential for a big pass play, or a big run after the catch, is very much in the cards with the Bills weak at safety and linebacker.

After covering how Buffalo's been slightly more vulnerable against the rush, too, I think we can fire up Samuel's combo line here with confidence. His numbers have fluctuated a ton this year, though it's been largely due to his nagging injuries, and while that's certainly a risk I don't think we can bank on him missing the majority of this game. If he's on the field, he'll hit this number.

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